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Sarah Pambianco
Researcher at University of Milan
Publications - 10
Citations - 531
Sarah Pambianco is an academic researcher from University of Milan. The author has contributed to research in topics: Autophagy & Duchenne muscular dystrophy. The author has an hindex of 8, co-authored 10 publications receiving 439 citations.
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Journal ArticleDOI
Autophagy as a new therapeutic target in Duchenne muscular dystrophy
C. De Palma,F Morisi,Stefania Cheli,Sarah Pambianco,Valentina Cappello,Valentina Cappello,Michela Vezzoli,Patrizia Rovere-Querini,Maurizio Moggio,Michela Ripolone,Maura Francolini,Marco Sandri,Emilio Clementi +12 more
TL;DR: This paper showed that autophagy is severely impaired in muscles from patients affected by Duchenne muscular dystrophy and mdx mice, a model of the disease, with accumulation of damaged organelles.
Journal ArticleDOI
Nitric oxide inhibition of Drp1-mediated mitochondrial fission is critical for myogenic differentiation
C. De Palma,Sestina Falcone,S. Pisoni,Sara Cipolat,Chris Panzeri,Sarah Pambianco,Addolorata Pisconti,Raffaele Allevi,Maria Teresa Bassi,Giulio Cossu,Tullio Pozzan,Salvador Moncada,Luca Scorrano,Silvia Brunelli,Emilio Clementi +14 more
TL;DR: It is shown that mitochondrial elongation is required for myogenesis to occur and that this event depends on the cellular generation of nitric oxide (NO), and that these effects of NO inhibition were not observed in myogenic precursor cells containing a dominant-negative form of Drp1.
Journal ArticleDOI
Deficient nitric oxide signalling impairs skeletal muscle growth and performance: involvement of mitochondrial dysregulation
Clara De Palma,F Morisi,Sarah Pambianco,Emma Assi,Thierry Touvier,Stefania Russo,Cristiana Perrotta,Vanina Romanello,Silvia Carnio,Valentina Cappello,Valentina Cappello,Paolo Pellegrino,Claudia Moscheni,Maria Teresa Bassi,Marco Sandri,Davide Cervia,Davide Cervia,Emilio Clementi +17 more
TL;DR: The results indicate that nNOSμ/NO is required to regulate key homeostatic mechanisms in skeletal muscle, namely mitochondrial bioenergetics and network remodelling, UPRmt and autophagy.
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Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin
Davide Cervia,Davide Cervia,Emma Assi,Clara De Palma,Clara De Palma,Matteo Giovarelli,Laura Bizzozero,Sarah Pambianco,Ilaria Di Renzo,Silvia Zecchini,Claudia Moscheni,Chiara Vantaggiato,Patrizia Procacci,Emilio Clementi,Emilio Clementi,Cristiana Perrotta +15 more
TL;DR: The fact that A-SMase in melanomas affects mTOR-regulated autophagy and plays a central role in cisplatin efficacy encourages pre-clinical testing on the modulation of A- SMase levels/activity as possible novel anti-neoplastic strategy.
Journal ArticleDOI
Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.
Daniela Tosoni,Sarah Pambianco,Blanche Ekalle Soppo,Silvia Zecchini,Giovanni Bertalot,Giancarlo Pruneri,Giuseppe Viale,Pier Paolo Di Fiore,Salvatore Pece +8 more
TL;DR: The data provide a pre‐clinical proof‐of‐concept that targeting Numb/p53 results in a specific anti‐CSC therapy in human BCs and corrected the defective self‐renewal properties of Numb‐deficient CSCs and inhibited CSC expansion, with a marked effect on tumorigenicity and metastasis.