S
Saraswati Sukumar
Researcher at Johns Hopkins University School of Medicine
Publications - 262
Citations - 28255
Saraswati Sukumar is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 77, co-authored 248 publications receiving 26027 citations. Previous affiliations of Saraswati Sukumar include Tufts University & Salk Institute for Biological Studies.
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HOXB7 is an ERα cofactor in the activation of HER2 and multiple ER target genes leading to endocrine resistance
Kideok Jin,Sunju Park,Wei Wen Teo,Preethi Korangath,Soonweng Cho,Takahiro Yoshida,Balázs Győrffy,Chirayu P. Goswami,Harikrishna Nakshatri,Leigh Ann Cruz,Weiqiang Zhou,Hongkai Ji,Ying Su,Muhammad B. Ekram,Zhengsheng Wu,Tao Zhu,Kornelia Polyak,Saraswati Sukumar +17 more
TL;DR: This paper showed that HOXB7-ERα complex enhances transcription of many ERα target genes including HER2 and showed that myc, stabilized via phosphorylation mediated by EGFR-HER2 signaling, inhibits transcription of miRNA-196a, a HOX-B7 repressor.
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Intraductal administration of transferrin receptor-targeted immunotoxin clears ductal carcinoma in situ in mouse models of breast cancer—a preclinical study
Guannan Wang,Alok Kumar,Wan-Jun Ding,Preethi Korangath,Tapan K. Bera,Junxia Wei,Priya Pai,Kathleen L. Gabrielson,Ira Pastan,Saraswati Sukumar +9 more
TL;DR:
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Combining the strength of genomics, nanoparticle technology, and direct intraductal delivery for breast cancer treatment.
Wei Wen Teo,Saraswati Sukumar +1 more
TL;DR: This study strengthens the concept of targeting overexpressed genes by using small interfering RNA and bypassing systemic immunity through local intraductal delivery by developing HOXA1-small interfering RNA nanoparticles.
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Breast-Specific Epigenetic Regulation of DeltaNp73 and Its Role in DNA-Damage-Response of BRCA1-Mutated Human Mammary Epithelial Cells.
Ayelet Avraham,Susanna Feldman,Soonweng Cho,Ayala Kol,Lior Heler,Emmanuela Riklin-Nahmias,Avishay Sella,Tamar Karni,Tanir M. Allweis,Saraswati Sukumar,Ella Evron +10 more
TL;DR: Breast-specific induction of deltaNp73 promotes survival of BRCA1-deficient mammary epithelial cells upon DNA damage, which might result in the accumulation of genomic alterations and allow the outgrowth of breast cancers.
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Development of an Automated Liquid Biopsy Assay for Methylated Markers in Advanced Breast Cancer
Mary Jo Fackler,Suzana Tulac,Neesha Venkatesan,Adam Aslam,Timothy de Guzman,Claudia Mercado-Rodriguez,Leslie Cope,Bradley M. Downs,Abdul Hussain Vali,Wan-Jun Ding,Jennifer Lehman,R. L. Denbow,Jeffrey Reynolds,M Buckley,Kala Visvanathan,Christopher B. Umbricht,Antonio C. Wolff,Vered Stearns,Michael Bates,Edwin W. Lai,Saraswati Sukumar +20 more
TL;DR: The development and technical validation of an automated Liquid Biopsy for Breast Cancer Methylation (LBx-BCM) prototype, a DNA methylation detection cartridge assay that is simple to perform and quantitatively detects nine methylated markers within 4.5 h.