S
Saraswati Sukumar
Researcher at Johns Hopkins University School of Medicine
Publications - 262
Citations - 28255
Saraswati Sukumar is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 77, co-authored 248 publications receiving 26027 citations. Previous affiliations of Saraswati Sukumar include Tufts University & Salk Institute for Biological Studies.
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Journal ArticleDOI
Epigenetic Inactivation of the Potential Tumor Suppressor Gene FOXF1 in Breast Cancer
Pang Kuo Lo,Ji Shin Lee,Xiaohui Liang,Liangfeng Han,Tsuyoshi Mori,Mary Jo Fackler,Helen Sadik,Pedram Argani,Tej K. Pandita,Saraswati Sukumar +9 more
TL;DR: expression profiling of cell cycle regulatory genes showed that abrogation of FOXF1 function resulted in increased expression of E2F-induced genes involved in promoting the progression of S and G(2) phases, suggesting thatFOXF1 is required for maintaining the stringency of DNA replication and genomic stability.
Journal ArticleDOI
Ductal Access for Prevention and Therapy of Mammary Tumors
Satoshi Murata,Scott L. Kominsky,Mustafa Vali,Zhe Zhang,Elizabeth Garrett-Mayer,Dorian Korz,David L. Huso,Sharyn D. Baker,James Barber,Elizabeth M. Jaffee,R. Todd Reilly,Saraswati Sukumar +11 more
TL;DR: The efficacy of intraductally administered anticancer agents 4-hydroxytamoxifen and pegylated liposomal doxorubicin (PLD) in the prevention and treatment of breast cancer is shown using the rat N-methyl-N'-nitrosourea-induced and spontaneous HER-2/neu transgenic mouse (neu-N) models of Breast cancer.
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Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas.
TL;DR: It is suggested that those events responsible for the critical stages of breast cancer development occur independently and in an uncoordinated manner.
Journal ArticleDOI
Role of Homeobox Genes in Normal Mammary Gland Development and Breast Tumorigenesis
Hexin Chen,Saraswati Sukumar +1 more
TL;DR: Recent studies of homeobox genes in breast cancer cells and primary tumors indicate that they may also play a contributory or causal role in tumorigenesis by regulating the cell cycle, apoptosis, angiogenesis, and/or metastasis.
Journal ArticleDOI
Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.
Sibgat Choudhury,Sibgat Choudhury,Vanessa Almendro,Vanessa F. Merino,Zhenhua Wu,Reo Maruyama,Reo Maruyama,Ying Su,Ying Su,Filipe C. Martins,Filipe C. Martins,Mary Jo Fackler,Marina Bessarabova,Adam Kowalczyk,Thomas C. Conway,Bryan Beresford-Smith,Geoff Macintyre,Yu-Kang Cheng,Zoila A. Lopez-Bujanda,Antony Kaspi,Rong Hu,Judith Robens,Judith Robens,Tatiana Nikolskaya,Vilde Drageset Haakensen,Stuart J. Schnitt,Stuart J. Schnitt,Pedram Argani,Gabrielle Ethington,Laura Panos,Michael Grant,Jason Clark,William Herlihy,S. Joyce Lin,G. L. Chew,Erik W. Thompson,April Greene-Colozzi,Andrea L. Richardson,Andrea L. Richardson,Gedge D. Rosson,Malcolm C. Pike,Judy Garber,Yuri Nikolsky,Joanne L. Blum,Alfred Au,E. Shelley Hwang,Rulla M. Tamimi,Rulla M. Tamimi,Franziska Michor,Izhak Haviv,X. Shirley Liu,Saraswati Sukumar,Kornelia Polyak +52 more
TL;DR: The results suggest that pathways controlling p27(+) mammary epithelial cells and the numbers of these cells relate to breast cancer risk and can be explored for cancer risk assessment and prevention.