S
Saraswati Sukumar
Researcher at Johns Hopkins University School of Medicine
Publications - 262
Citations - 28255
Saraswati Sukumar is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 77, co-authored 248 publications receiving 26027 citations. Previous affiliations of Saraswati Sukumar include Tufts University & Salk Institute for Biological Studies.
Papers
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Journal ArticleDOI
Automated and rapid detection of cancer in suspicious axillary lymph nodes in patients with breast cancer.
Juanjuan Li,Juanjuan Li,Bradley M. Downs,Leslie Cope,Mary Jo Fackler,Xiuyun Zhang,Chuan gui Song,Christopher J. VandenBussche,Kejing Zhang,Yong Han,Yufei Liu,Suzana Tulac,Neesha Venkatesan,Timothy de Guzman,Chuang Chen,Edwin W. Lai,Jingping Yuan,Saraswati Sukumar +17 more
TL;DR: In this paper, the authors proposed a 5-h automated GeneXpert system-based prototype breast cancer detection assay (BCDA) that quantitatively measures DNA methylation in ten tumor-specific gene markers.
Patent
Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor
Saraswati Sukumar,Liangfeng Han +1 more
TL;DR: In this article, the basic helix loop helix transcription factor HEYL was found to be overexpressed in breast cancer cells, and therapeutic compositions and methods for altering the levels and expression of HEYL of the invention, thereby treating a neoplasia, as well as compositions and method for diagnosing a prostate cancer.
Proceedings ArticleDOI
Abstract 5593: A combination of HDAC inhibitor Entinostat (MS-275), All Trans Retinoic Acid (ATRA) and low dose Doxorubicin causes regression of established xenografts of triple negative breast cancer
Nguyen Nguyen,Preethi Korangath,Gauri Sabnis,Angela Brodie,Peter Ordentlich,Vered Stearns,Saraswati Sukumar +6 more
TL;DR: In vitro, human TNBC cell lines responded significantly better to the triple combination compared to the drugs used singly or in combination with MS-275, and no significant weight loss was observed in any of the groups.
Journal ArticleDOI
Clonal selection in tamoxifen resistance.
Kideok Jin,Saraswati Sukumar +1 more
TL;DR: MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity.
Journal ArticleDOI
Breast Hormone Concentrations in Random Fine-Needle Aspirates of Healthy Women Associate with Cytological Atypia and Gene Methylation
Oukseub Lee,Richard Heinz,David Ivancic,Miguel Muzzio,Robert T. Chatterton,Carola M. Zalles,Kara Keeney,Belinda Phan,Dachao Liu,Denise M. Scholtens,Mary Jo Fackler,Vered Stearns,Saraswati Sukumar,Seema A. Khan +13 more
TL;DR: The authors' data indicate that future larger studies of breast steroid hormones along with other parameters are feasible, and significant associations of breast androgen concentrations with breast density and gene methylation warrant future study.