S
Saraswati Sukumar
Researcher at Johns Hopkins University School of Medicine
Publications - 262
Citations - 28255
Saraswati Sukumar is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 77, co-authored 248 publications receiving 26027 citations. Previous affiliations of Saraswati Sukumar include Tufts University & Salk Institute for Biological Studies.
Papers
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Journal ArticleDOI
Mutational hotspot in exon 20 of PIK3CA in breast cancer among Singapore Chinese.
Xiaohui Liang,Quek Choon Lau,Manuel Salto-Tellez,Thomas C. Putti,Marie Loh,Saraswati Sukumar +5 more
TL;DR: The results suggest that mutation of PIK3CA might contribute to development of early stage breast cancer and could provide a potent target for early diagnosis and therapy.
Journal ArticleDOI
Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays
Zufeng Guo,Zhiqiang Cheng,Jingxin Wang,Jingxin Wang,Wukun Liu,Wukun Liu,Hanjing Peng,Yuefan Wang,A. V.Subba Rao,Ruo jing Li,Ruo jing Li,Xue Ying,Xue Ying,Preethi Korangath,Maria V. Liberti,Yingjun Li,Yongmei Xie,Yongmei Xie,Sam Y. Hong,Cordelia Schiene-Fischer,Gunter Fischer,Jason W. Locasale,Saraswati Sukumar,Heng Zhu,Jun O. Liu +24 more
TL;DR: RgA was found to inhibit glucose uptake, leading to a decrease in cellular ATP synthesis, activation of AMP-dependent kinase, inhibition of mTOR signaling, and induction of cell cycle arrest and apoptosis in cancer cells.
Journal ArticleDOI
DNA Methylation Markers for Breast Cancer Detection in the Developing World.
Bradley M. Downs,Claudia Mercado-Rodriguez,Ashley Cimino-Mathews,Chuang Chen,Jing Ping Yuan,Eunice van den Berg,Leslie Cope,Fernando Schmitt,Gary Tse,Syed Z. Ali,Danielle Meir-Levi,Rupali Sood,Juanjuan Li,Juanjuan Li,Andrea L. Richardson,Marina Mosunjac,Monica Rizzo,Suzana Tulac,Kriszten Kocmond,Timothy de Guzman,Edwin W. Lai,Brian Rhees,Michael Bates,Antonio C. Wolff,Edward Gabrielson,Susan C. Harvey,Christopher B. Umbricht,Kala Visvanathan,Kala Visvanathan,Mary Jo Fackler,Saraswati Sukumar +30 more
TL;DR: A fast and accurate methylation marker–based automated cartridge system to detect breast cancer in FNA samples has the potential to prioritize cancer over benign tissues for expedited pathologic evaluation in poorly resourced countries.
Journal ArticleDOI
DNA promoter hypermethylation in nipple fluid: a potential tool for early breast cancer detection.
Jolien S. de Groot,Cathy B. Moelans,Sjoerd G. Elias,Mary Jo Fackler,Robert van Domselaar,Karijn P M Suijkerbuijk,Arjen J. Witkamp,Saraswati Sukumar,Paul J. van Diest,Elsken van der Wall +9 more
TL;DR: Cancerous nipple fluid contains increased levels of methylation of tumor suppressor genes that potentially could serve as a biomarker for early breast cancer detection.
Patent
Claudins as Markers for Early Detection, Diagnosis, Prognosis and as Targets of Therapy for Breast and Metastatic Brain or Bone Cancer
TL;DR: In this article, the level of expression of the proteins claudin 1, 3, 4, and 7 in tissue or cell samples is detected and used for diagnosis, prognosis, and treatment of breast cancer and metastatic brain cancer.