S
Saraswati Sukumar
Researcher at Johns Hopkins University School of Medicine
Publications - 262
Citations - 28255
Saraswati Sukumar is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 77, co-authored 248 publications receiving 26027 citations. Previous affiliations of Saraswati Sukumar include Tufts University & Salk Institute for Biological Studies.
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HOX Genes: Major Actors in Resistance to Selective Endocrine Response Modifiers
TL;DR: Recent progress in understanding of the functioning of HOX genes and regulation of their expression by hormones is reviewed and the contributions of several members of the HOX gene family to endocrine resistant breast cancer are discussed.
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Tissue specific DNA methylation in normal human breast epithelium and in breast cancer.
Ayelet Avraham,Soonweng Cho,Ronit Uhlmann,Mia Leonov Polak,Judith Sandbank,Tami Karni,Itzhak Pappo,Ruvit Halperin,Zvi Vaknin,Avishay Sella,Saraswati Sukumar,Ella Evron +11 more
TL;DR: Interestingly, TRIM29 regulation in breast tumors clustered according to the PAM50 classification, and was repressed in the estrogen receptor positive tumors, particularly in the more proliferative luminal B subtype.
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Effective treatment of ductal carcinoma in situ with a HER-2-targeted alpha-particle emitting radionuclide in a preclinical model of human breast cancer
Takahiro Yoshida,Kideok Jin,Hong Song,Sunju Park,David L. Huso,Zhe Zhang,Han Liangfeng,Charles Zhu,Frank Bruchertseifer,Alfred Morgenstern,George Sgouros,Saraswati Sukumar +11 more
TL;DR: It is shown that the therapeutic efficacy of intraductal 225Ac-trastuzumab in a DCIS model of human SUM225 cancer cells in NSG mice was significantly higher than intravenous administration, with no kidney toxicity or loss of body weight.
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Molecular cloning and chromosomal localization of Chinese hamster telomeric protein chTRF1. Its potential role in chromosomal instability
Lubomir B. Smilenov,Wilfredo Mellado,Pulivarthi H. Rao,Satin G. Sawant,Christopher B. Umbricht,Saraswati Sukumar,Tej K. Pandita +6 more
TL;DR: These studies suggest that chTRF1 does not bind the interstitial telomeric repeats, and its presence at the metaphase chromosome ends is limited, which could be a factor contributing to frequent karyotypic alterations observed in Chinese hamster cells.
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Improvement of stability and efficacy of C16Y therapeutic peptide via molecular self-assembly into tumor-responsive nanoformulation
Yanping Ding,Tianjiao Ji,Ying Zhao,Yinlong Zhang,Xiaozheng Zhao,Ruifang Zhao,Jiayan Lang,Xiao Zhao,Jian Shi,Saraswati Sukumar,Guangjun Nie +10 more
TL;DR: For the first time, it is demonstrated that a simple nanoformulation using a functional antitumor peptide as the building block can show innate antitumors activity and also provide a nanoplatform for combination therapy, opening a new avenue for the design of antitUMor nanotherapeutics.