S
Sarmila Majumder
Researcher at Ohio State University
Publications - 60
Citations - 5210
Sarmila Majumder is an academic researcher from Ohio State University. The author has contributed to research in topics: DNA methylation & Methyltransferase. The author has an hindex of 35, co-authored 55 publications receiving 4879 citations. Previous affiliations of Sarmila Majumder include McGill University & Florida State University College of Arts and Sciences.
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Journal ArticleDOI
MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1
Tyler E. Miller,Kalpana Ghoshal,Bhuvaneswari Ramaswamy,Satavisha Roy,Jharna Datta,Charles L. Shapiro,Samson T. Jacob,Sarmila Majumder +7 more
TL;DR: This is the first study demonstrating a relationship between miR-221/222 expression and HER2/neu overexpression in primary breast tumors that are generally resistant to tamoxifen therapy, and provides the rationale for the application of altered expression of specific miRNAs as a predictive tamoxIFen-resistant breast cancer marker.
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Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
Jharna Datta,Huban Kutay,Mohd W. Nasser,Gerard J. Nuovo,Bo Wang,Sarmila Majumder,Chang Gong Liu,Stefano Volinia,Carlo M. Croce,Thomas D. Schmittgen,Kalpana Ghoshal,Samson T. Jacob +11 more
TL;DR: Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down- regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis.
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5-Aza-Deoxycytidine Induces Selective Degradation of DNA Methyltransferase 1 by a Proteasomal Pathway That Requires the KEN Box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal
Kalpana Ghoshal,Jharna Datta,Sarmila Majumder,Shoumei Bai,Huban Kutay,Tasneem Motiwala,Samson T. Jacob +6 more
TL;DR: Results demonstrate a unique mechanism for the selective degradation of DNMT1, the maintenance DNA methyltransferase, by well-known DNA-hypomethylating agents and indicate that covalent bond formation between the enzyme and 5-aza-CdR-incorporated DNA is not essential for enzyme degradation.
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Down-regulation of Micro-RNA-1 (miR-1) in Lung Cancer SUPPRESSION OF TUMORIGENIC PROPERTY OF LUNG CANCER CELLS AND THEIR SENSITIZATION TO DOXORUBICIN-INDUCED APOPTOSIS BY miR-1
Mohd W. Nasser,Jharna Datta,Gerard J. Nuovo,Huban Kutay,Tasneem Motiwala,Sarmila Majumder,Bo Wang,Saul Suster,Saul Suster,Samson T. Jacob,Kalpana Ghoshal +10 more
TL;DR: It is reported that micro-RNA-1 (miR-1), abundant in the cardiac and smooth muscles, is expressed in the lung and is down-regulated in human primary lung cancer tissues and cell lines and has potential therapeutic application against lung cancers.
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TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
TL;DR: Upregulation of miR-181b at early stages of feeding CDAA diet promotes hepatocarcinogenesis and enhanced resistance of HCC cells to the anticancer drug doxorubicin.