Saskia Pollefeyt

TL;DR: It is reported that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES)16,17, and even more impaired in homozygous D1-VEGF- deficient (VDGF-/-) T-ES embryos, resulting in death at mid-gestation.

TL;DR: The recombinant lectin-like domain of TM suppresses PMN adhesion to ECs, diminishes cytokine-induced increase in nuclear factor κB and activation of ERK1/2, and rescues ECs from serum starvation, suggesting that TM has antiinflammatory properties in addition to its role in coagulation and fibrinolysis.

TL;DR: The presence of distinct isoforms of survivin that are expressed differentially suggests that survivin plays a complex role in regulating apoptosis.

TL;DR: This is the first in vivo documentation that survivin modulates caspase activation and that Fas-mediated hepatic apoptosis is regulated by survivin via mitochondrial pathways.

TL;DR: Mammalian blood contains an enzymatic system, called the fibrinolytic system, that has been claimed to play a role in several phenomena associated with proteolysis, including blood clot dissolution, thrombosis, hemostasis, atherosclerosis, ovulation, embryo implantation, embryogenesis, wound healing, malignancy, and brain function.