S
Saskia Pollefeyt
Researcher at Katholieke Universiteit Leuven
Publications - 10
Citations - 5071
Saskia Pollefeyt is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Thrombomodulin & Survivin. The author has an hindex of 8, co-authored 10 publications receiving 4947 citations. Previous affiliations of Saskia Pollefeyt include University of Toronto.
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Journal ArticleDOI
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Peter Carmeliet,Valérie Ferreira,Georg Breier,Saskia Pollefeyt,Lena Kieckens,Marina Gertsenstein,Michaela Fahrig,Ann Vandenhoeck,Kendraprasad Harpal,Carmen Eberhardt,Cathérine Declercq,Judy Pawling,Lieve Moons,Desire Collen,Werner Risau,Andras Nagy,Andras Nagy +16 more
TL;DR: It is reported that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES)16,17, and even more impaired in homozygous D1-VEGF- deficient (VDGF-/-) T-ES embryos, resulting in death at mid-gestation.
Journal ArticleDOI
The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways.
Edward M. Conway,Marlies Van de Wouwer,Saskia Pollefeyt,Kerstin Jurk,Hugo Van Aken,Astrid De Vriese,Jeffrey I. Weitz,Hartmut Weiler,Peter Hellings,Paul Schaeffer,Jean-Marc Herbert,Desire Collen,G Theilmeier +12 more
TL;DR: The recombinant lectin-like domain of TM suppresses PMN adhesion to ECs, diminishes cytokine-induced increase in nuclear factor κB and activation of ERK1/2, and rescues ECs from serum starvation, suggesting that TM has antiinflammatory properties in addition to its role in coagulation and fibrinolysis.
Journal ArticleDOI
Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
Edward M. Conway,Saskia Pollefeyt,Saskia Pollefeyt,Jan Cornelissen,Jan Cornelissen,Inky DeBaere,Inky DeBaere,Marta Steiner-Mosonyi,Marta Steiner-Mosonyi,Kelly Ong,Kelly Ong,Mathijs Baens,Mathijs Baens,Desiré Collen,Desiré Collen,Andre C. Schuh,Andre C. Schuh +16 more
TL;DR: The presence of distinct isoforms of survivin that are expressed differentially suggests that survivin plays a complex role in regulating apoptosis.
Journal ArticleDOI
Deficiency of survivin in transgenic mice exacerbates Fas-induced apoptosis via mitochondrial pathways
Edward M. Conway,Saskia Pollefeyt,Marta Steiner-Mosonyi,Wei Luo,Astrid DeVriese,Florea Lupu,Françoise Bono,Nathalie Leducq,Frédérique Dol,Paul Schaeffer,Desire Collen,Jean-Marc Herbert +11 more
TL;DR: This is the first in vivo documentation that survivin modulates caspase activation and that Fas-mediated hepatic apoptosis is regulated by survivin via mitochondrial pathways.
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Biological Effects of Disruption of the Tissue-Type Plasminogen Activator, Urokinase-Type Plasminogen Activator, and Plasminogen Activator Inhibitor-1 Genes in Micea
Peter Carmeliet,Peter Carmeliet,Ann Bouché,C. De Clercq,S Janssen,Saskia Pollefeyt,Sabine Wyns,Richard C. Mulligan,Desire Collen +8 more
TL;DR: Mammalian blood contains an enzymatic system, called the fibrinolytic system, that has been claimed to play a role in several phenomena associated with proteolysis, including blood clot dissolution, thrombosis, hemostasis, atherosclerosis, ovulation, embryo implantation, embryogenesis, wound healing, malignancy, and brain function.