S
Saumyadipta Pyne
Researcher at University of Pittsburgh
Publications - 58
Citations - 1440
Saumyadipta Pyne is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Population & Computer science. The author has an hindex of 15, co-authored 53 publications receiving 1263 citations. Previous affiliations of Saumyadipta Pyne include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors
Valentina Vaira,Giuseppe Fedele,Saumyadipta Pyne,Ester Fasoli,Giorgia Zadra,Dyane Bailey,Eric L. Snyder,Alice Faversani,Guido Coggi,Richard Flavin,Silvano Bosari,Massimo Loda +11 more
TL;DR: An ex vivo, reproducible, rapid and personalized culture method to investigate antitumoral pharmacological properties that preserves the original cancer microenvironment is perfected and may have a significant impact on patient selection for clinical trials and in predicting response to small-molecule inhibitor therapy.
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The Cell Cycle–Regulated Genes of Schizosaccharomyces pombe
Anna Oliva,Adam P. Rosebrock,Francisco Ferrezuelo,Saumyadipta Pyne,Haiying Chen,Steve Skiena,Bruce Futcher,Janet Leatherwood +7 more
TL;DR: Preliminary evidence is found for a nearly genome-wide oscillation in gene expression: 2,000 or more genes undergo slight oscillations in expression as a function of the cell cycle, although whether this is adaptive, or incidental to other events in the cell, such as chromatin condensation, the authors do not know.
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Bayesian inference for finite mixtures of univariate and multivariate skew-normal and skew-t distributions.
TL;DR: This work develops Bayesian inference based on data augmentation and Markov chain Monte Carlo (MCMC) sampling that allows robust modeling of high-dimensional multimodal and asymmetric data generated by popular biotechnological platforms such as flow cytometry.
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AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Carmen Priolo,Saumyadipta Pyne,Joshua Rose,Erzsébet Ravasz Regan,Giorgia Zadra,Cornelia Photopoulos,Stefano Cacciatore,Denise Schultz,Natalia Scaglia,Jonathan E. McDunn,Angelo M. De Marzo,Massimo Loda +11 more
TL;DR: Findings show how prostate tumors undergo a metabolic reprogramming that reflects their molecular phenotypes, with implications for the development of metabolic diagnostics and targeted therapeutics.
Journal ArticleDOI
Spatial proximity to fibroblasts impacts molecular features and therapeutic sensitivity of breast cancer cells influencing clinical outcomes
Andriy Marusyk,Doris P. Tabassum,Michalina Janiszewska,Michalina Janiszewska,Andrew E. Place,Andrew E. Place,Anne Trinh,Anne Trinh,Andrii I. Rozhok,Saumyadipta Pyne,Jennifer L. Guerriero,Jennifer L. Guerriero,Shaokun Shu,Shaokun Shu,Muhammad B. Ekram,Muhammad B. Ekram,Alexander Ishkin,Daniel P. Cahill,Yuri Nikolsky,Timothy A. Chan,Mothaffar F. Rimawi,Susan G. Hilsenbeck,Rachel Schiff,Kent Osborne,Antony Letai,Antony Letai,Kornelia Polyak +26 more
TL;DR: These studies identify CAF-induced physiologically and clinically relevant changes in cancer cells and offer novel approaches for overcoming microenvironment-mediated therapeutic resistance.