S
Scott A. Chasse
Researcher at University of North Carolina at Chapel Hill
Publications - 12
Citations - 780
Scott A. Chasse is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: GTPase-activating protein & RGS Proteins. The author has an hindex of 9, co-authored 11 publications receiving 729 citations. Previous affiliations of Scott A. Chasse include Uniformed Services University of the Health Sciences & University of Virginia.
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Journal ArticleDOI
A Seven-Transmembrane RGS Protein That Modulates Plant Cell Proliferation
Jin-Gui Chen,Francis S. Willard,Jirong Huang,Jiansheng Liang,Scott A. Chasse,Alan M. Jones,David P. Siderovski +6 more
TL;DR: An RGS protein (AtRGS1) in Arabidopsis that has a predicted structure similar to a GPCR as well as an RGS box with GTPase accelerating activity is identified, suggesting that AtRGS 1 is a critical modulator of plant cell proliferation.
Journal ArticleDOI
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking
Richard Sherva,Kirk C. Wilhelmsen,Cynthia S. Pomerleau,Scott A. Chasse,John P. Rice,Sandy M. Snedecor,Laura J. Bierut,Rosalind J. Neuman,Ovide F. Pomerleau +8 more
TL;DR: The polymorphism in the CHRNA5 subunit was shown to be associated significantly with enhanced pleasurable responses to initial cigarettes in regular smokers in an a priori test, suggesting that phenotypes related to subjective experiences upon smoking experimentation may mediate the development of nicotine dependence.
Journal ArticleDOI
Structural basis of RXR-DNA interactions
Qiang Zhao,Scott A. Chasse,Srikripa Devarakonda,Michael Sierk,Bijan Ahvazi,Fraydoon Rastinejad +5 more
TL;DR: The structure shows how a gene-regulatory site can induce conformational changes in a transcription factor that promote homo-cooperative assembly and illustrates how site selection is achieved in this large eukaryotic transcription factor family through discrete protein-protein interactions and the use of tandem DNA binding sites with characteristic spacings.
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Genome-scale analysis reveals Sst2 as the principal regulator of mating pheromone signaling in the yeast Saccharomyces cerevisiae.
Scott A. Chasse,Paul L. Flanary,Stephen C. Parnell,Nan Hao,Jiyoung Y. Cha,David P. Siderovski,Henrik G. Dohlman +6 more
TL;DR: It is suggested that Sst2 is the principal regulator of Gpa1-mediated signaling in vivo but that other proteins also contribute in distinct ways to pathway regulation.
Journal ArticleDOI
Olfactory copy number association with age at onset of Alzheimer disease.
Chad A. Shaw,Yi Li,Joanna Wiszniewska,Scott A. Chasse,S. N.Y. Zaidi,W. Jin,Brian Dawson,Brian Dawson,Kirk C. Wilhelmsen,J. R. Lupski,John W. Belmont,Rachelle S. Doody,Kinga Szigeti,Kinga Szigeti +13 more
TL;DR: High copy number in the olfactory receptor region on 14q11.2 is associated with younger age at onset of AD, and the association was found for each APOE4 gene dosage.