S
Scott C. Kogan
Researcher at University of California, San Francisco
Publications - 144
Citations - 13813
Scott C. Kogan is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Leukemia & Acute promyelocytic leukemia. The author has an hindex of 54, co-authored 136 publications receiving 12806 citations. Previous affiliations of Scott C. Kogan include University of California, Berkeley & University of Chicago.
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Journal ArticleDOI
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Johannes Zuber,Junwei Shi,Junwei Shi,Eric Wang,Amy R. Rappaport,Amy R. Rappaport,Harald Herrmann,Edward Allan R. Sison,Daniel Magoon,Jun Qi,Katharina Blatt,Mark Wunderlich,Meredith J. Taylor,Christopher Johns,Agustin Chicas,James C. Mulloy,Scott C. Kogan,Patrick Brown,Peter Valent,James E. Bradner,Scott W. Lowe,Scott W. Lowe,Scott W. Lowe,Christopher R. Vakoc +23 more
TL;DR: The results establish small-molecule inhibition of Brd4 as a promising therapeutic strategy in AML and, potentially, other cancers, and highlight the utility of RNA interference screening for revealing epigenetic vulnerabilities that can be exploited for direct pharmacological intervention.
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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
Hans-Guido Wendel,Elisa de Stanchina,Jordan S. Fridman,Jordan S. Fridman,Abba Malina,Sagarika Ray,Scott C. Kogan,Carlos Cordon-Cardo,Jerry Pelletier,Scott W. Lowe +9 more
TL;DR: It is shown that Akt promotes tumorigenesis and drug resistance by disrupting apoptosis, and that disruption of Akt signalling using the mTOR inhibitor rapamycin reverses chemoresistance in lymphomas expressing Akt, but not in those with other apoptotic defects.
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An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A.
TL;DR: By means of this method, carrier detection and prenatal diagnosis of hemophilia in two families are performed with use of the factor VIII intragenic polymorphisms identified by the restriction enzymes Bc/I and XbaI.
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Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity
Yuchen Chien,Claudio Scuoppo,Xiaowo Wang,Xueping Fang,Brian M. Balgley,Jessica E. Bolden,Prem K. Premsrirut,Weijun Luo,Agustin Chicas,Cheng S. Lee,Scott C. Kogan,Scott W. Lowe +11 more
TL;DR: It is found that NF-κB acts as a master regulator of the SASP, influencing the expression of more genes than RB and p53 combined, and a tumor-suppressive function of NF-σB that contributes to the outcome of cancer therapy is identified.
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A PMLRARα transgene initiates murine acute promyelocytic leukemia
Diane Storer Brown,Scott C. Kogan,Eric Lagasse,Irving L. Weissman,Myriam Alcalay,Pier Giuseppe Pelicci,Susan K. Atwater,J. Michael Bishop +7 more
TL;DR: The transgenic mice described here provide an apparently accurate model for human APL that includes clear evidence of tumor progression and should be useful for exploring the molecular pathogenesis of APL and the mechanisms of the therapeutic response to retinoic acid.