Scott E. LaPatra

TL;DR: It is shown that IgT, an immunoglobulin isotype of unknown function, acts like a mucosal antibody, and detected responses of rainbow trout IgT to an intestinal parasite only in the gut, whereas IgM responses were confined to the serum.

TL;DR: The findings support the idea that B cells evolved from an ancestral phagocytic cell type and provide an evolutionary framework for understanding the close relationship between mammalian B lymphocytes and macrophages.

TL;DR: The findings suggest that, regardless of their phylogenetic origin and tissue localization, the chief immunoglobulins of all mucosa-associated lymphoid tissue operate under the guidance of primordially conserved principles.

TL;DR: It is found that NALT is present in rainbow trout and that it resembles other teleost mucosa-associated lymphoid tissues, and is capable of mounting strong anti-viral immune responses following nasal delivery of a live attenuated viral vaccine.

TL;DR: It is shown that trout and other teleost fish contain a single CD80/86 gene, thus suggesting that this gene may represent the ancestor from which CD80 and CD86 arose by gene duplication in more evolved species.