J
Jeffrey B. Bonanno
Researcher at Albert Einstein College of Medicine
Publications - 89
Citations - 5926
Jeffrey B. Bonanno is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Structural genomics & Protein structure. The author has an hindex of 37, co-authored 87 publications receiving 5336 citations. Previous affiliations of Jeffrey B. Bonanno include Columbia University & Rockefeller University.
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Journal ArticleDOI
Protein production and purification.
Susanne Gräslund,Pär Nordlund,J Weigelt,B M Hallberg,James E. Bray,Opher Gileadi,Stefan Knapp,Udo Oppermann,Cheryl H. Arrowsmith,Raymond Hui,J Ming,Sirano Dhe-Paganon,Park H-W.,Alexei Savchenko,Adelinda Yee,Aled M. Edwards,Renaud Vincentelli,Christian Cambillau,R Kim,Kim S-H.,Zihe Rao,Yunyu Shi,Thomas C. Terwilliger,Kim C-Y.,Hung L-W.,Geoffrey S. Waldo,Yoav Peleg,Shira Albeck,Tamar Unger,Orly Dym,Jaime Prilusky,Joel L. Sussman,Raymond C. Stevens,Scott A. Lesley,Scott A. Lesley,Ian A. Wilson,Ian A. Wilson,Andrzej Joachimiak,Frank R. Collart,Irina Dementieva,Mark I. Donnelly,William H. Eschenfeldt,Youngchang Kim,Lucy Stols,Ruiying Wu,M. Zhou,Stephen K. Burley,J.S. Emtage,J.M. Sauder,D.A. Thompson,Kevin Bain,John G. Luz,Tarun Gheyi,F Zhang,Shane Atwell,Steven C. Almo,Jeffrey B. Bonanno,Andras Fiser,Soumya Swaminathan,F.W. Studier,Mark R. Chance,Andrej Sali,Thomas Acton,Rong Xiao,L Zhao,L C Ma,John F. Hunt,Liang Tong,Kellie Cunningham,Masayori Inouye,Stephen Anderson,Haleema Janjua,Ritu Shastry,C K Ho,D Wang,Hao Wang,M Jiang,Gaetano T. Montelione,David I. Stuart,Raymond J. Owens,S Daenke,Anja Schütz,Udo Heinemann,S Yokoyama,Konrad Büssow,Kristin C. Gunsalus,Kristin C. Gunsalus +86 more
TL;DR: This review presents methods that could be applied at the outset of any project, a prioritized list of alternate strategies and a list of pitfalls that trip many new investigators.
Journal ArticleDOI
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin
Petr G. Leiman,Petr G. Leiman,Marek Basler,Udupi A. Ramagopal,Jeffrey B. Bonanno,J. Michael Sauder,Stefan Pukatzki,Stephen K. Burley,Steven C. Almo,John J. Mekalanos +9 more
TL;DR: It is proposed that T6SS is a multicomponent structure whose extracellular part resembles both structurally and functionally a bacteriophage tail, an efficient machine that translocates proteins and DNA across lipid membranes into cells.
Journal ArticleDOI
Recognition of polyadenylate RNA by the poly(A)-binding protein
Rahul C. Deo,Jeffrey B. Bonanno,Jeffrey B. Bonanno,Nahum Sonenberg,Stephen K. Burley,Stephen K. Burley +5 more
TL;DR: The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution and it is shown that the convex dorsum of RRM1/2 displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with translation initiation factors and regulatory proteins.
Journal ArticleDOI
Structural genomics: beyond the human genome project.
Stephen K. Burley,Stephen K. Burley,Steven C. Almo,Jeffrey B. Bonanno,Jeffrey B. Bonanno,Malcolm Capel,Mark R. Chance,Terry Gaasterland,Dawei Lin,Andrej Sali,F. William Studier,Subramanyam Swaminathan +11 more
TL;DR: A program of high-throughput X-ray crystallography aimed at developing a comprehensive mechanistic understanding of normal and abnormal human and microbial physiology at the molecular level is about to embark on.
Journal ArticleDOI
Structural genomics: A pipeline for providing structures for the biologist
Mark R. Chance,Anne R. Bresnick,Stephen K. Burley,Stephen K. Burley,Jiansheng Jiang,Christopher D. Lima,Andrej Sali,Steven C. Almo,Jeffrey B. Bonanno,John A. Buglino,Simon J. Boulton,Hua Chen,Hua Chen,Narayanan Eswar,Guoshun He,Guoshun He,Raymond Y. Huang,Valentin A. Ilyin,Linda McMahan,Ursula Pieper,Soumya S. Ray,Marc Vidal,Li Kai Wang +22 more
TL;DR: Structural biologists have embraced high-throughput biology by developing and implementing technologies that will enable the structures of hundreds of protein domains to be solved in a relatively short time.