S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
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Journal ArticleDOI
Genomic Diversity and Fitness of E. coli Strains Recovered from the Intestinal and Urinary Tracts of Women with Recurrent Urinary Tract Infection
Swaine L. Chen,Meng Wu,Jeffrey P. Henderson,Thomas M. Hooton,Michael E. Hibbing,Scott J. Hultgren,Jeffrey I. Gordon +6 more
TL;DR: Comparative genomic and functional studies reveal that E. coli strains from women with recurrent urinary tract infection can move between gut and urinary tract without a fitness trade-off, emphasizing the need to widen the consideration of potential reservoirs for strains causing recurrent UTI.
Functional Genomic Studies of Uropathogenic Escherichia coli and Host Urothelial Cells when Intracellular Bacterial
TL;DR: In this article, the authors used GeneChips and/orquantita-tive reverse transcriptase PCR to study mice inoculated with UTI89,a sequenced isolate, have revealed a complex life cycle that includes formation of intracellular bacterial communities(IBCs) in bladder urothelial cells.
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Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice.
Andrew L. Kau,Steven M. Martin,William R. Lyon,Ericka Hayes,Michael G. Caparon,Scott J. Hultgren +5 more
TL;DR: It is demonstrated that E. faecalis has tropism for the kidneys in the urinary tracts of mice and that this system can be used to study factors involved in the pathogenesis of urinary tract infections.
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G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.
TL;DR: It is found that UPEC infection induces expression of several pro‐inflammatory cytokines including granulocyte colony‐stimulating factor (G‐CSF, CSF‐3), not previously known to be involved in the host response to UTI.
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EbpA vaccine antibodies block binding of Enterococcus faecalis to fibrinogen to prevent catheter-associated bladder infection in mice.
TL;DR: An EbpA-based vaccine that prevented catheter-associated infection by E. faecalis in mice was developed and a critical step in biofilm formation was identified and targeted, and a new strategy for the prevention of catheters-associated urinary tract infections was provided.