Scott J. Hultgren

TL;DR: The (p)ppGpp-CodY network is identified as an important contributor to enterococcal virulence in catheterized mouse bladder and supports that basal ( p)pp Gpp pools and CodY promote virulence through maintenance of a balanced metabolism during adverse conditions.

TL;DR: In this paper, the authors considered compounds of formula (1a) or (1b), or (2a) and (2b) and the salts, esters and amides thereof thereof wherein Z is S, SO, SO2 or O; each of R?1, R2 and R3? is independently substituted or unsubstituted alkyl (1-10C), substituted or unused acyl (2-11C), substitute or unused aryl (6-14C), substituting or unused pyridyl (7-

TL;DR: In host-pathogen interactions pili often activate a cascade of events that will ultimately determine whether the microbe will remain extracellular or trigger processes that will allow its uptake into host cells and/or activation of host defense mechanisms.

TL;DR: A new class of antibiotics based on a ring-fused 2-pyridone backbone is described, which are active against vancomycin-resistant enterococci (VRE), a serious threat as classified by the Centers for Disease Control and Prevention, and other multidrug-resistant Gram-positive bacteria.

TL;DR: This chapter describes techniques that have been used to analyze the biogenesis of pili via the chaperone usher pathway and model systems to study host-pathogen interactions mediated by type 1 piliated E. coli.