S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
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Journal ArticleDOI
Immune Modulation by Group B Streptococcus Influences Host Susceptibility to Urinary Tract Infection by Uropathogenic Escherichia coli
TL;DR: Taken together, these studies suggest that despite low titers, the presence of GBS at the time of polymicrobial UT exposure may be an overlooked risk factor for chronic pyelonephritis and recurrent UTI in susceptible groups, even if it is outcompeted and thus absent by thetime of diagnosis.
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Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling
Manuela K. Hospenthal,Adam Redzej,Karen W. Dodson,Marta Ukleja,Brandon Frenz,Catarina Rodrigues,Scott J. Hultgren,Frank DiMaio,Edward H. Egelman,Gabriel Waksman +9 more
TL;DR: An atomic model of the P pilus generated from a 3.8 Å resolution cryo-electron microscopy reconstruction is presented, providing the molecular basis for the rod’s remarkable mechanical properties and illuminates its role in pilus secretion.
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Design, synthesis and evaluation of peptidomimetics based on substituted bicyclic 2-pyridones-targeting virulence of uropathogenic E. coli.
Veronica Åberg,Magnus Sellstedt,Mattias Hedenström,Jerome S. Pinkner,Scott J. Hultgren,Fredrik Almqvist +5 more
TL;DR: Rational design is applied to produce four classes of extended peptidomimetics based on two bioactive 2-pyridones to suggest that the limited in vivo potencies of the analogues are either uptake/distribution related or due to loss in binding specificity.
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Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections
Ana L. Flores-Mireles,Jennifer N. Walker,Aaron M. Potretzke,Henry L. Schreiber,Jerome S. Pinkner,Tyler M. Bauman,Alyssa M. Park,Alana Desai,Scott J. Hultgren,Michael G. Caparon +9 more
TL;DR: The mechanism of protection using passive transfer of immune sera to show that antisera blocking EbpANTD-fibrinogen interactions not only is prophylactic but also can act therapeutically to reduce bacterial titers of an existing infection is explored.
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Characterization of a novel murine model of Staphylococcus saprophyticus urinary tract infection reveals roles for Ssp and SdrI in virulence.
Kimberly A. Kline,Molly A. Ingersoll,Hailyn V. Nielsen,Türkan Sakinc,Birgitta Henriques-Normark,Sören Gatermann,Michael G. Caparon,Scott J. Hultgren +7 more
TL;DR: It is shown that S. saprophyticus preferentially infects C3H/HeN murine kidneys instead of the bladder, a trait observed for multiple clinical isolates, and a useful model system for studying factors involved in the pathogenesis of this Gram-positive uropathogen.