S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
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P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips
TL;DR: It is reported here that the adhesin is a component of distinct fibrillar structures present at the tips of the pili, which mediate the binding of uropathogenic E. coli to a digalactoside receptor determinant present in the urinary tract epithelium.
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Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili.
TL;DR: This work changes the extracellular colonization functional paradigm of pili by demonstrating their intracellular role in biofilm formation.
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Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli.
Solomon Langermann,Roland Möllby,Jeanne E. Burlein,Susan R. Palaszynski,C. Gale Auguste,Anthony DeFusco,Robert Strouse,Mark A. Schenerman,Scott J. Hultgren,Jerome S. Pinkner,Jan Winberg,Lena Guldevall,Mats Söderhäll,Kiyohito Ishikawa,Staffan Normark,Scott Koenig +15 more
TL;DR: Findings suggest that a vaccine based on the FimH adhesin of E. coli type 1 pili may have utility in preventing cystitis in humans.
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Filamentation by Escherichia coli subverts innate defenses during urinary tract infection.
TL;DR: It is demonstrated that transient SulA-mediated inhibition of cell division is essential for UPEC virulence in the murine model of cystitis and facilitates the transition to additional rounds of IBC formation by subverting innate immune responses.
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Multiple pathways allow protein secretion across the bacterial outer membrane.
TL;DR: Secretion pathways can be organized into evolutionarily and functionally related groups, which highlight their relationship with organelle biogenesis.