S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
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Journal ArticleDOI
Subinhibitory Antibiotic Therapy Alters Recurrent Urinary Tract Infection Pathogenesis through Modulation of Bacterial Virulence and Host Immunity
Lee W. Goneau,Lee W. Goneau,Lee W. Goneau,Thomas J. Hannan,Roderick A. MacPhee,Drew J. Schwartz,Jean M. Macklaim,Gregory B. Gloor,Hassan Razvi,Gregor Reid,Gregor Reid,Scott J. Hultgren,Jeremy P. Burton,Jeremy P. Burton +13 more
TL;DR: The study indicates that certain agents used for antibiotic prophylaxis have the potential to complicate infections, and identifies novel risk factors associated with antibiotic therapy when dosing strategies fall below subtherapeutic levels.
Journal ArticleDOI
Adhesin presentation in bacteria requires molecular chaperones and ushers.
Charles Hal Jones,Françoise Jacob-Dubuisson,Karen W. Dodson,Meta J. Kuehn,Lynn N. Slonim,Rob Striker,Scott J. Hultgren +6 more
TL;DR: The intention of this review is to describe general mechanisms used by gram-negative bacteria to present adhesins in configurations which make them able to recognize receptors on the surface of epithelial cells.
Journal ArticleDOI
Streptozocin-induced diabetic mouse model of urinary tract infection.
TL;DR: A murine model of diabetic UTI using the pancreatic islet β-cell toxin streptozocin to initiate diabetes in healthy mouse backgrounds is characterized and can provide a powerful tool for dissecting this infection in the multifactorial setting of diabetes.
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AhrC and Eep Are Biofilm Infection-Associated Virulence Factors in Enterococcus faecalis
Kristi L. Frank,Pascale S. Guiton,Aaron M. T. Barnes,Dawn A. Manias,Olivia N. Chuang-Smith,Petra L. Kohler,Adam R. Spaulding,Scott J. Hultgren,Patrick M. Schlievert,Gary M. Dunny +9 more
TL;DR: It is demonstrated that the transcriptional regulator AhrC and the protease Eep, which was previously shown to be an endocarditis virulence factor, are also required for full virulence in murine CAUTI and can be classified as enterococcal biofilm-associated virulence factors.
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The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo.
Corey S. Westfall,Ana L. Flores-Mireles,Ana L. Flores-Mireles,John I. Robinson,Aaron J L Lynch,Scott J. Hultgren,Jeffrey P. Henderson,Petra Anne Levin +7 more
TL;DR: Clinical relevant concentrations of triclosan are reported to have increased E. coli and MRSA tolerance to bactericidal antibiotics as much as 10,000-fold in vitro and reduced antibiotic efficacy up to 100- fold in a mouse urinary tract infection model.