S
Scott J. Hultgren
Researcher at Washington University in St. Louis
Publications - 393
Citations - 42958
Scott J. Hultgren is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Pilus & Bacterial adhesin. The author has an hindex of 109, co-authored 380 publications receiving 38674 citations. Previous affiliations of Scott J. Hultgren include University College London & Vrije Universiteit Brussel.
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Journal ArticleDOI
Bad bugs and beleaguered bladders: interplay between uropathogenic Escherichia coli and innate host defenses.
TL;DR: This paper showed that infection with type 1-pili E. coli can trigger a number of host responses, including cytokine production, inflammation, and exfoliation of infected bladder epithelial cells.
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Structural Basis of Chaperone Function and Pilus Biogenesis
Frederic G. Sauer,Klaus Fütterer,Jerome S. Pinkner,Karen W. Dodson,Scott J. Hultgren,Gabriel Waksman +5 more
TL;DR: The structure of the PapD-PapK chaperone-subunit complex suggests that during pilus biogenesis, every subunit completes the immunoglobulin-like fold of its neighboring subunit via a mechanism termed donor strand exchange.
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Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation
Lynette Cegelski,Jerome S. Pinkner,Neal D. Hammer,Corinne K. Cusumano,Chia S. Hung,Erik Chorell,Veronica Åberg,Jennifer N. Walker,Patrick C. Seed,Fredrik Almqvist,Matthew George Chapman,Scott J. Hultgren +11 more
TL;DR: The ability of FN075 to block the biogenesis of both curli and type 1 pili endows unique anti-biofilm and anti-virulence activities on these compounds.
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Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin
Julie Bouckaert,Jenny Berglund,Mark A. Schembri,Erwin De Genst,Lieve Cools,Manfred Wuhrer,Chia-Suei Hung,Jerome S. Pinkner,Rikard Slättegård,Anton V. Zavialov,Devapriya Choudhury,Solomon Langermann,Scott J. Hultgren,Lode Wyns,Per Klemm,Stefan Oscarson,Stefan D. Knight,Henri De Greve +17 more
TL;DR: These relative FimH affinities correlate exceptionally well with the relative concentrations of the same glycans needed for the inhibition of adherence of type 1 piliated E. coli.
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Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection
Chia-Suei Hung,Julie Bouckaert,Julie Bouckaert,Danielle Hung,Jerome S. Pinkner,Charlotte Widberg,Anthony DeFusco,C. Gale Auguste,Robert Strouse,Solomon Langermann,Gabriel Waksman,Scott J. Hultgren +11 more
TL;DR: The structure/function analysis demonstrated that the binding of the monosaccharide α‐D‐mannose is the primary bladder cell receptor for uropathogenic E. coli and that this event requires a highly conserved FimH binding pocket.