M
Michelle A. Carmell
Researcher at Massachusetts Institute of Technology
Publications - 23
Citations - 9355
Michelle A. Carmell is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA interference & Argonaute. The author has an hindex of 13, co-authored 23 publications receiving 8755 citations. Previous affiliations of Michelle A. Carmell include Wellesley College & Watson School of Biological Sciences.
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Journal ArticleDOI
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
Jidong Liu,Michelle A. Carmell,Michelle A. Carmell,Fabiola V. Rivas,Carolyn G. Marsden,J. Michael Thomson,Ji-Joon Song,Scott M. Hammond,Leemor Joshua-Tor,Gregory J. Hannon +9 more
TL;DR: The evidence supports a model in which Argonaute contributes “Slicer” activity to RISC, providing the catalytic engine for RNAi.
Journal ArticleDOI
Dicer is essential for mouse development.
Emily Bernstein,Sang Yong Kim,Michelle A. Carmell,Michelle A. Carmell,Elizabeth P. Murchison,Heather L. Alcorn,Mamie Z. Li,Alea A. Mills,Stephen J. Elledge,Kathryn V. Anderson,Gregory J. Hannon +10 more
TL;DR: A role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development is suggested.
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A germline-specific class of small RNAs binds mammalian Piwi proteins
TL;DR: It is shown that MIWI, a murine Piwi protein, binds a previously uncharacterized class of ∼29–30-nucleotide RNAs that are highly abundant in testes and are named Piwi-interacting RNAs (piRNAs), suggesting a role in gametogenesis.
Journal ArticleDOI
MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline.
Michelle A. Carmell,Angélique Girard,Angélique Girard,Henk J. G. van de Kant,Déborah Bourc'his,Timothy H. Bestor,Dirk G. de Rooij,Gregory J. Hannon +7 more
TL;DR: The observations suggest a conserved function for Piwi-clade proteins in the control of transposons in the germline, and this work examines the effects of disrupting the gene encoding the third family member, MIWI2.
Journal ArticleDOI
The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
TL;DR: Argonaute proteins comprise a highly conserved protein family that is involved in a variety of RNA silencing phenomena in a diverse set of organisms and may ultimately reveal the reach of these pathways into the basic biological mechanisms that underlie a range of human diseases.