S
Sebastian Zimmer
Researcher at University Hospital Bonn
Publications - 81
Citations - 1098
Sebastian Zimmer is an academic researcher from University Hospital Bonn. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 12, co-authored 45 publications receiving 716 citations.
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Journal ArticleDOI
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Sebastian Zimmer,Alena Grebe,Siril Skaret Bakke,Siril Skaret Bakke,Niklas Bode,Bente Halvorsen,Thomas Ulas,Mona Skjelland,Dominic De Nardo,Dominic De Nardo,Dominic De Nardo,Larisa I. Labzin,Anja Kerksiek,Chris Hempel,Michael T. Heneka,Victoria Hawxhurst,Michael L. Fitzgerald,Jonel Trebicka,Jonel Trebicka,Ingemar Björkhem,Jan-Åke Gustafsson,Marit Westerterp,Alan R. Tall,Samuel D. Wright,Terje Espevik,Joachim L. Schultze,Georg Nickenig,Dieter Lütjohann,Eicke Latz +28 more
TL;DR: CD treatment of murine atherosclerosis reduced atherosclerotic plaque size and CC load and promoted plaque regression even with a continued cholesterol-rich diet, and CD beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human Atherosclerosis.
Journal ArticleDOI
Activation of endothelial toll-like receptor 3 impairs endothelial function.
Sebastian Zimmer,Martin Steinmetz,Tobias Asdonk,Inga Motz,Christoph Coch,Evelyn Hartmann,Winfried Barchet,Sven Wassmann,Gunther Hartmann,Georg Nickenig +9 more
TL;DR: Investigation of whether stimulation of TLR3 influences endothelial biology in mice found elevated levels of circulating endothelial progenitor cells in polyinosine polycytidylic acid–treated mice, although they displayed increased endothelial dysfunction.
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Aortic Valve Stenosis: From Basic Mechanisms to Novel Therapeutic Targets.
Philip Roger Goody,Mohammed Rabiul Hosen,Dominik Christmann,Sven Thomas Niepmann,Andreas Zietzer,Matti Adam,Florian Bönner,Sebastian Zimmer,Georg Nickenig,Felix Jansen +9 more
TL;DR: This review summarizes the current knowledge of pathomechanisms involved in aortic valve calcification and points out novel treatment strategies.
Journal ArticleDOI
CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function.
Vedat Tiyerili,Sebastian Zimmer,Suzin Jung,Kerstin Wassmann,Claas P. Naehle,Dieter Lütjohann,Andreas Zimmer,Georg Nickenig,Sven Wassmann +8 more
TL;DR: In this paper, the effects of CB1-R inhibition on vascular smooth muscle cells (VSMCs) and aortic tissue of mice were validated in vitro and in vivo.
Journal ArticleDOI
Diffuse Myocardial Inflammation in COVID-19 Associated Myocarditis Detected by Multiparametric Cardiac Magnetic Resonance Imaging.
Julian A. Luetkens,Alexander Isaak,Sebastian Zimmer,Jacob Nattermann,Alois M. Sprinkart,Christoph Boesecke,Gereon Rieke,Christian Frédéric Zachoval,Annkristin Heine,Markus Velten,Georg D. Duerr +10 more
TL;DR: CMR parameters fulfilled the revised 2018 Lake Louise criteria for the diagnosis of myocarditis, and a 79-year-old male was moved to the intensive care unit.