Gereon Rieke

TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

TL;DR: This article performed RNA-seq of whole blood cell transcriptomes and granulocyte preparations from mild and severe COVID-19 patients and analyzed the data using a combination of conventional and data-driven co-expression analysis.

TL;DR: In this article, the authors performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies.

TL;DR: Comparison of COVID-19 blood transcriptomes with those of a collection of over 2,600 samples derived from 11 different viral infections, inflammatory diseases and independent control samples revealed highly specific transcriptome signatures for CO VID-19, which predicted patient subgroup-specific drug candidates targeting the dysregulated systemic immune response of the host.

TL;DR: CMR parameters fulfilled the revised 2018 Lake Louise criteria for the diagnosis of myocarditis, and a 79-year-old male was moved to the intensive care unit.