L
Larisa I. Labzin
Researcher at University of Queensland
Publications - 31
Citations - 3766
Larisa I. Labzin is an academic researcher from University of Queensland. The author has contributed to research in topics: Inflammation & Medicine. The author has an hindex of 15, co-authored 21 publications receiving 2892 citations. Previous affiliations of Larisa I. Labzin include Laboratory of Molecular Biology & University of Bonn.
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Journal ArticleDOI
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Jia Xue,Susanne Schmidt,Jil Sander,Astrid M. Draffehn,Wolfgang Krebs,Inga Quester,Dominic De Nardo,Trupti D. Gohel,Martina Emde,Lisa Schmidleithner,Hariharasudan Ganesan,Andrea Niño-Castro,Michael R. Mallmann,Larisa I. Labzin,Heidi Theis,Michael Kraut,Marc Beyer,Eicke Latz,Eicke Latz,Tom C. Freeman,Thomas Ulas,Joachim L. Schultze +21 more
TL;DR: By integrating murine data from the ImmGen project, this work proposes a refined, activation-independent core signature for human and murine macrophages that serves as a framework for future research into regulation of macrophage activation in health and disease.
Journal ArticleDOI
A Method for the Acute and Rapid Degradation of Endogenous Proteins
Dean Clift,William A. McEwan,Larisa I. Labzin,Vera Konieczny,Binyam Mogessie,Leo C. James,Melina Schuh +6 more
TL;DR: Trim-Away harnesses the cellular protein degradation machinery to remove unmodified native proteins within minutes of application, which minimizes the risk that phenotypes are compensated and that secondary, non-specific defects accumulate over time.
Journal ArticleDOI
High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3
Dominic De Nardo,Larisa I. Labzin,Hajime Kono,Reiko Seki,Susanne Schmidt,Marc Beyer,Dakang Xu,Sebastian Zimmer,Catharina Lahrmann,Frank A. Schildberg,Johanna Vogelhuber,Michael Kraut,Thomas Ulas,Anja Kerksiek,Wolfgang Krebs,Niklas Bode,Alena Grebe,Michael L. Fitzgerald,Nicholas J. Hernandez,Bryan R.G. Williams,Percy A. Knolle,Manfred Kneilling,Martin Röcken,Dieter Lütjohann,Samuel D. Wright,Joachim L. Schultze,Eicke Latz +26 more
TL;DR: The transcriptional regulator ATF3 is identified, as an HDL-inducible target gene in macrophages that downregulates the expression of Toll-like receptor (TLR)-induced proinflammatory cytokines and may explain the broad anti-inflammatory and metabolic actions of HDL.
Journal ArticleDOI
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
Kate Schroder,Katharine M. Irvine,Martin S. Taylor,Nilesh J. Bokil,Kim-Anh Lê Cao,Kelly-Anne Masterman,Larisa I. Labzin,Colin A. Semple,Ronan Kapetanovic,Lynsey Fairbairn,Altuna Akalin,Geoffrey J. Faulkner,J K Baillie,Milena Gongora,Carsten O. Daub,Hideya Kawaji,Geoffrey J. McLachlan,Nick Goldman,Sean M. Grimmond,Piero Carninci,Harukazu Suzuki,Yoshihide Hayashizaki,Boris Lenhard,David A. Hume,Matthew J. Sweet +24 more
TL;DR: Notably, regulatory divergence was also associated with enhanced interspecies promoter conservation and the genes controlled by complex, highly conserved promoters that facilitate dynamic regulation are also the most susceptible to evolutionary change.
Journal ArticleDOI
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Sebastian Zimmer,Alena Grebe,Siril Skaret Bakke,Siril Skaret Bakke,Niklas Bode,Bente Halvorsen,Thomas Ulas,Mona Skjelland,Dominic De Nardo,Dominic De Nardo,Dominic De Nardo,Larisa I. Labzin,Anja Kerksiek,Chris Hempel,Michael T. Heneka,Victoria Hawxhurst,Michael L. Fitzgerald,Jonel Trebicka,Jonel Trebicka,Ingemar Björkhem,Jan-Åke Gustafsson,Marit Westerterp,Alan R. Tall,Samuel D. Wright,Terje Espevik,Joachim L. Schultze,Georg Nickenig,Dieter Lütjohann,Eicke Latz +28 more
TL;DR: CD treatment of murine atherosclerosis reduced atherosclerotic plaque size and CC load and promoted plaque regression even with a continued cholesterol-rich diet, and CD beneficially affects key mechanisms of atherogenesis, it may therefore be used clinically to prevent or treat human Atherosclerosis.