Sebastien Coassolo

TL;DR: Although tumors comprised variable proportions of cells with theMITF-high and MITF-low gene expression signatures characteristic of melanoma cultures, primary tumors also comprised cells expressing markers of both signatures defining a novel cell state in tumors in vivo.

TL;DR: It is shown that MITF associates the NURF chromatin-remodelling factor in melanoma cells and shRNA-mediated silencing of the NurF subunit BPTF revealed its essential role in several melanoma cell lines and in untransformed melanocytes in vitro.

TL;DR: In this melanoma model, somatic inactivation that the catalytic Brg1 (Smarca4) subunit of the SWI/SNF complex and the scaffolding Bptf sub unit of the NuRF complex delayed tumour formation and deregulated large and overlapping gene expression programs essential for normal tumour cell growth.

TL;DR: This work provides unique insight as to how conversion of arginines to citrulline impacts key interactions within PKM2 that act in concert to reprogram its activity as an additional mechanism regulating this important enzyme.

TL;DR: The long-term genetic evolution of cutaneous metastatic melanoma is described, characterized by an unexpected phenotypic stability and neoantigen-driven clonal selection.