P
Patrick Laurette
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 663
Patrick Laurette is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Microphthalmia-associated transcription factor & SOX10. The author has an hindex of 4, co-authored 6 publications receiving 516 citations.
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Journal ArticleDOI
Melanoma addiction to the long non-coding RNA SAMMSON.
Eleonora Leucci,Roberto Vendramin,Marco Spinazzi,Patrick Laurette,Mark Fiers,Jasper Wouters,Enrico Radaelli,Sven Eyckerman,Carina Leonelli,Katrien Vanderheyden,Aljosja Rogiers,Els Hermans,Pieter Baatsen,Stein Aerts,Frédéric Amant,Stefan Van Aelst,Stefan Van Aelst,Joost van den Oord,Bart De Strooper,Irwin Davidson,Denis L. J. Lafontaine,Kris Gevaert,Jo Vandesompele,Pieter Mestdagh,Jean-Christophe Marine +24 more
TL;DR: The results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner and is expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses.
Journal ArticleDOI
Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells
Patrick Laurette,Thomas Strub,Dana Koludrovic,Céline Keime,Stéphanie Le Gras,Hannah Seberg,Eric Van Otterloo,Hana Imrichova,Robert Siddaway,Stein Aerts,Robert A. Cornell,Gabrielle Mengus,Irwin Davidson +12 more
TL;DR: A comprehensive MITF interactome is defined identifying novel cofactors involved in transcription, DNA replication and repair, and chromatin organisation and it is shown that MITF interacts with a PBAF chromatin remodelling complex comprising BRG1 and CHD7.
Journal ArticleDOI
Chromatin-Remodelling Complex NURF Is Essential for Differentiation of Adult Melanocyte Stem Cells
Dana Koludrovic,Patrick Laurette,Thomas Strub,Céline Keime,Madeleine Le Coz,Sebastien Coassolo,Gabrielle Mengus,Lionel Larue,Irwin Davidson +8 more
TL;DR: It is shown that MITF associates the NURF chromatin-remodelling factor in melanoma cells and shRNA-mediated silencing of the NurF subunit BPTF revealed its essential role in several melanoma cell lines and in untransformed melanocytes in vitro.
Journal ArticleDOI
Chromatin remodellers Brg1 and Bptf are required for normal gene expression and progression of oncogenic Braf-driven mouse melanoma.
Patrick Laurette,Sebastien Coassolo,Guillaume Davidson,Isabelle Michel,Giovanni Gambi,Wenjin Yao,Pierre Sohier,Mei Li,Gabrielle Mengus,Lionel Larue,Lionel Larue,Irwin Davidson +11 more
TL;DR: In this melanoma model, somatic inactivation that the catalytic Brg1 (Smarca4) subunit of the SWI/SNF complex and the scaffolding Bptf sub unit of the NuRF complex delayed tumour formation and deregulated large and overlapping gene expression programs essential for normal tumour cell growth.
Peer ReviewDOI
Author response: Transcription factor MITF and remodeller BRG1 define chromatin organisation at regulatory elements in melanoma cells
Patrick Laurette,Thomas Strub,Dana Koludrovic,Céline Keime,Stéphanie Le Gras,Hannah Seberg,Eric Van Otterloo,Hana Imrichova,Robert Siddaway,Stein Aerts,Robert A. Cornell,Gabrielle Mengus,Irwin Davidson +12 more