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Richard J. Mazzaccaro
Researcher at Albert Einstein College of Medicine
Publications - 11
Citations - 2423
Richard J. Mazzaccaro is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Cytotoxic T cell & CD1. The author has an hindex of 9, co-authored 10 publications receiving 2384 citations. Previous affiliations of Richard J. Mazzaccaro include Yeshiva University & Wilmington University.
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Journal ArticleDOI
CD1-restricted T cell recognition of microbial lipoglycan antigens.
Peter A. Sieling,Delphi Chatterjee,Steven A. Porcelli,Theodore I. Prigozy,Richard J. Mazzaccaro,T. Soriano,Barry R. Bloom,Michael B. Brenner,Mitchell Kronenberg,Patrick J. Brennan,Robert L. Modlin +10 more
TL;DR: It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes, which resulted in T cells activated by LAM producing interferon gamma and were cytolytic.
Journal ArticleDOI
Differential effects of cytolytic T cell subsets on intracellular infection
Steffen Stenger,Richard J. Mazzaccaro,Koichi Uyemura,Sungae Cho,Peter F. Barnes,Jean Pierre Rosat,Alessandro Sette,Michael B. Brenner,Steven A. Porcelli,Barry R. Bloom,Robert L. Modlin +10 more
TL;DR: The data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.
Journal Article
An anti-inflammatory role for gamma delta T lymphocytes in acquired immunity to Mycobacterium tuberculosis.
TL;DR: The data suggest that gammadelta T cells perhaps play an important role by influencing local cellular traffic, promoting the influx of lymphocytes and monocytes, and limiting the access of inflammatory cells that do not contribute to protection but may cause tissue damage.
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Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
Alexandra O. Sousa,Richard J. Mazzaccaro,Robert G. Russell,Francis K. Lee,Oliver C. Turner,Seokmann Hong,Luc Van Kaer,Barry R. Bloom +7 more
TL;DR: It is suggested here that both classical and nonclassical MHC class I-restricted T cells, distinct from CD1d-restricted cells, may be involved in protective immune responses against tuberculosis.
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Antimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis
Sungae Cho,Vijay Mehra,Vijay Mehra,Sybille Thoma-Uszynski,Steffen Stenger,Natalya V. Serbina,Richard J. Mazzaccaro,JoAnne L. Flynn,Peter F. Barnes,Scott Southwood,Esteban Celis,Barry R. Bloom,Robert L. Modlin,Alessandro Sette +13 more
TL;DR: CD8+ cytotoxic T lymphocytes reduced the viability of the intracellular MTB, providing evidence that CD8+ T cell recognition of MHC class I-restricted epitopes of these MTB antigens can contribute to effective immunity against the pathogen.