S
Seung-Hwan Kwon
Researcher at Johns Hopkins University School of Medicine
Publications - 52
Citations - 3456
Seung-Hwan Kwon is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Kinase & Protein kinase B. The author has an hindex of 23, co-authored 50 publications receiving 2406 citations. Previous affiliations of Seung-Hwan Kwon include Korea Institute of Science and Technology & Sungkyunkwan University.
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Journal ArticleDOI
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Seung Pil Yun,Tae In Kam,Nikhil Panicker,SangMin Kim,Yumin Oh,Jong-Sung Park,Seung-Hwan Kwon,Yong Joo Park,Senthilkumar S. Karuppagounder,Hyejin Park,Sangjune Kim,Nayeon Oh,Nayoung Alice Kim,Saebom Lee,Saurav Brahmachari,Xiaobo Mao,Jun Hee Lee,Manoj Kumar,Daniel An,Sung Ung Kang,Yunjong Lee,Kang Choon Lee,Dong Hee Na,Dong-Hoon Kim,Sang Hun Lee,Viktor V. Roschke,Shane A. Liddelow,Zoltan Mari,Ben A. Barres,Valina L. Dawson,Seulki Lee,Ted M. Dawson,Han Seok Ko +32 more
TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.
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Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice
Seung-Hwan Kwon,Ha-Kyung Lee,Ji-Ah Kim,Sa-Ik Hong,Hyoung-Chun Kim,Tae-Hyung Jo,Young-In Park,Chong-Kil Lee,Yong-Bin Kim,Seok-Yong Lee,Choon-Gon Jang +10 more
TL;DR: Results indicate that chlorogenic acid may exert anti-amnesic activity via inhibition of acetylcholinesterase and malondialdehyde in the hippocampus and frontal cortex in a dose-dependent manner.
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Graphene quantum dots prevent alpha-synucleinopathy in Parkinson's disease.
Dong-Hoon Kim,Je Min Yoo,Heehong Hwang,Junghee Lee,Suhyun Lee,Seung Pil Yun,Myung Jin Park,MinJun Lee,Seulah Choi,Sang Ho Kwon,Saebom Lee,Seung-Hwan Kwon,Sangjune Kim,Yong Joo Park,Misaki Kinoshita,Young-Ho Lee,Seokmin Shin,Seung R. Paik,Sung Joong Lee,Seulki Lee,Byung Hee Hong,Han Seok Ko +21 more
TL;DR: In this article, the authors show that GQDs exhibit anti-amyloid activity via direct interaction with alpha-synuclein (α-syn) aggregates and demonstrate that they have notable potency in not only inhibiting fibrillization of α-syn but also disaggregating mature fibrils in a time-dependent manner.
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GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers.
Sangjune Kim,Seung Pil Yun,Saebom Lee,George Essien Umanah,Veera Venkata Ratnam Bandaru,Xiling Yin,Peter Rhee,Senthilkumar S. Karuppagounder,Seung-Hwan Kwon,Hojae Lee,Xiaobo Mao,Dong-Hoon Kim,Akhilesh Pandey,Gabsang Lee,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +16 more
TL;DR: These studies provide mechanistic insights into how GBA1 regulates the transition from monomeric α- syn to α-syn tetramers and multimers and suggest unique therapeutic opportunities for PD and dementia with Lewy bodies.