Jae Cheol Lee

TL;DR: Induction of EMT may contribute to the decreased efficacy of therapy in primary and acquired resistance to gefitinib.

TL;DR: It is shown that small interfering RNA-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis.

TL;DR: It is found that EMT developed in a lung cancer patient who had an acquired resistance to erlotinib while there were no known resistant mechanisms such as T790M and MET amplification.

TL;DR: Comparison of induced pluripotent stem cell-derived endothelial cells from three families with unaffected mutation carriers, FPAH patients, and gender-matched controls identified features of UMC iPSC-ECs related to modifiers of BMPR2 signaling or to differentially expressed genes that could help inform development of future treatment strategies.

TL;DR: In this article, the β-adrenergic pathway was blunted in dilated cardiomyopathy (DCM) patients with a mutation in TNNT2, a sarcomeric protein.