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Ilkka Seppälä
Researcher at University of Tampere
Publications - 211
Citations - 11545
Ilkka Seppälä is an academic researcher from University of Tampere. The author has contributed to research in topics: Genome-wide association study & Population. The author has an hindex of 48, co-authored 210 publications receiving 9105 citations. Previous affiliations of Ilkka Seppälä include University of Helsinki & Helsinki University Central Hospital.
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Journal ArticleDOI
Integrative approaches for large-scale transcriptome-wide association studies.
Alexander Gusev,Alexander Gusev,Arthur Ko,Huwenbo Shi,Gaurav Bhatia,Gaurav Bhatia,Wonil Chung,Brenda W.J.H. Penninx,Rick Jansen,Eco J. C. de Geus,Dorret I. Boomsma,Fred A. Wright,Patrick F. Sullivan,Patrick F. Sullivan,Elina Nikkola,Marcus Alvarez,Mete Civelek,Aldons J. Lusis,Terho Lehtimäki,Emma Raitoharju,Mika Kähönen,Ilkka Seppälä,Olli T. Raitakari,Olli T. Raitakari,Johanna Kuusisto,Markku Laakso,Alkes L. Price,Alkes L. Price,Päivi Pajukanta,Bogdan Pasaniuc +29 more
TL;DR: A powerful strategy that integrates gene expression measurements with summary association statistics from large-scale genome-wide association studies (GWAS) to identify genes whose cis-regulated expression is associated with complex traits is introduced.
Posted ContentDOI
Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis
Urmo Võsa,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Silva Kasela,Natalia Pervjakova,Alvaes I,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Reyhan Sonmez,Andrew A. Brown,Andrew A. Brown,Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg-Guzman,Jarno Kettunen,Joseph E. Powell,Bernett Lee,Futao Zhang,Wibowo Arindrarto,Frank Beutner,Harm Brugge,Dmitreva J,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Mika Kähönen,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Hailiang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Rotzchke O,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Peter A C 't Hoen,Joachim Thiery,Anke Tönjes,van Dongen J,van Iterson M,Jan H. Veldink,Uwe Völker,C Wijmenga,Morris A. Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Z. Kutalik,Emmanouil T. Dermitzakis,Sven Bergmann,Timothy M. Frayling,van Meurs J,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,D.I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Kate Downes,Oliver Stegle,Alexis Battle,Jian Yang,Peter M. Visscher,Markus Scholz,Greg Gibson,Tõnu Esko,Lude Franke +100 more
TL;DR: It is observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting the ability to use cis- eZTLs to pinpoint causal genes within susceptibility loci.
Journal ArticleDOI
Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation
Carolina Roselli,Mark Chaffin,Lu-Chen Weng,Lu-Chen Weng,Stefanie Aeschbacher,Gustav Ahlberg,Christine M. Albert,Peter Almgren,Alvaro Alonso,Christopher D. Anderson,Christopher D. Anderson,Krishna G. Aragam,Krishna G. Aragam,Dan E. Arking,John Barnard,Traci M. Bartz,Emelia J. Benjamin,Emelia J. Benjamin,Nathan A. Bihlmeyer,Joshua C. Bis,Heather L. Bloom,Eric Boerwinkle,Erwin B. Bottinger,Jennifer A. Brody,Hugh Calkins,Archie Campbell,Thomas P. Cappola,John F. Carlquist,John F. Carlquist,Daniel I. Chasman,Daniel I. Chasman,Lin Y. Chen,Yii-Der Ida Chen,Eue Keun Choi,Seung Hoan Choi,Ingrid E. Christophersen,Ingrid E. Christophersen,Ingrid E. Christophersen,Mina K. Chung,John W. Cole,John W. Cole,David Conen,David Conen,James P. Cook,Harry J.G.M. Crijns,Michael J. Cutler,Scott M. Damrauer,Scott M. Damrauer,Brian R. Daniels,Dawood Darbar,Graciela Delgado,Joshua C. Denny,Martin Dichgans,Martin Dichgans,Marcus Dörr,Elton A. M. P. Dudink,Samuel C. Dudley,Nada Esa,Tõnu Esko,Tõnu Esko,Markku Eskola,Diane Fatkin,Diane Fatkin,Diane Fatkin,Stephan B. Felix,Ian Ford,Oscar H. Franco,Bastiaan Geelhoed,Raji P. Grewal,Raji P. Grewal,Vilmundur Gudnason,Xiuqing Guo,Namrata Gupta,Stefan Gustafsson,Rebecca Gutmann,Anders Hamsten,Tamara B. Harris,Caroline Hayward,Susan R. Heckbert,Susan R. Heckbert,Jussi Hernesniemi,Lynne J. Hocking,Albert Hofman,Andrea R. V. R. Horimoto,Jie Huang,Paul L. Huang,Jennifer E. Huffman,Erik Ingelsson,Erik Ingelsson,Esra Gucuk Ipek,Kaoru Ito,Jordi Jimenez-Conde,Jordi Jimenez-Conde,Renee Johnson,J. Wouter Jukema,Stefan Kääb,Mika Kähönen,Yoichiro Kamatani,John P. Kane,Adnan Kastrati,Sekar Kathiresan,Sekar Kathiresan,Petra Katschnig-Winter,Maryam Kavousi,Thorsten Kessler,Bas L.J.H. Kietselaer,Paulus Kirchhof,Marcus E. Kleber,Stacey Knight,Stacey Knight,José Eduardo Krieger,Michiaki Kubo,Lenore J. Launer,Jari Laurikka,Terho Lehtimäki,Kirsten Leineweber,Rozenn N. Lemaitre,Man Li,Man Li,Hong Euy Lim,Henry J. Lin,Honghuang Lin,Honghuang Lin,Lars Lind,Cecilia M. Lindgren,Marja-Liisa Lokki,Barry London,Ruth J. F. Loos,Siew-Kee Low,Yingchang Lu,Leo-Pekka Lyytikäinen,Peter W. Macfarlane,Patrik K. E. Magnusson,Anubha Mahajan,Rainer Malik,Alfredo José Mansur,Gregory M. Marcus,Lauren Margolin,Kenneth B. Margulies,Winfried März,Winfried März,David D. McManus,Olle Melander,Sanghamitra Mohanty,Jay A. Montgomery,Michael Morley,Andrew P. Morris,Martina Müller-Nurasyid,Andrea Natale,Saman Nazarian,Benjamin Neumann,Christopher Newton-Cheh,Christopher Newton-Cheh,Maartje N. Niemeijer,Kjell Nikus,Peter M. Nilsson,Raymond Noordam,Heidi Oellers,Morten S. Olesen,Marju Orho-Melander,Sandosh Padmanabhan,Hui Nam Pak,Guillaume Paré,Guillaume Paré,Nancy L. Pedersen,Joanna Pera,Alexandre C. Pereira,David J. Porteous,Bruce M. Psaty,Bruce M. Psaty,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Clive R. Pullinger,Daniel J. Rader,Lena Refsgaard,Marta Ribasés,Marta Ribasés,Paul M. Ridker,Michiel Rienstra,Lorenz Risch,Dan M. Roden,Jonathan Rosand,Jonathan Rosand,Michael A. Rosenberg,Michael A. Rosenberg,Natalia S. Rost,Natalia S. Rost,Jerome I. Rotter,Samir Saba,Roopinder K. Sandhu,Renate B. Schnabel,Katharina Schramm,Heribert Schunkert,Claudia Schurman,Stuart A. Scott,Ilkka Seppälä,Christian M. Shaffer,Svati H. Shah,Alaa Shalaby,Alaa Shalaby,Jaemin Shim,M. Benjamin Shoemaker,Joylene E. Siland,Juha Sinisalo,Moritz F. Sinner,Agnieszka Slowik,Albert V. Smith,Blair H. Smith,J. Gustav Smith,J. Gustav Smith,Jonathan D. Smith,Nicholas L. Smith,Nicholas L. Smith,Elsayed Z. Soliman,Nona Sotoodehnia,Bruno H. Stricker,Albert Y. Sun,Han Sun,Jesper Hastrup Svendsen,Toshihiro Tanaka,Kahraman Tanriverdi,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Sébastien Thériault,Sébastien Thériault,Stella Trompet,Nathan R. Tucker,Nathan R. Tucker,Arnljot Tveit,Arnljot Tveit,André G. Uitterlinden,Pim van der Harst,Isabelle C. Van Gelder,David R. Van Wagoner,Niek Verweij,Efthymia Vlachopoulou,Uwe Völker,Biqi Wang,Peter Weeke,Peter Weeke,Bob Weijs,Raul Weiss,Stefan Weiss,Quinn S. Wells,Kerri L. Wiggins,Jorge A. Wong,Daniel Woo,Bradford B. Worrall,Pil Sung Yang,Jie Yao,Zachary T. Yoneda,Tanja Zeller,Lingyao Zeng,Steven A. Lubitz,Steven A. Lubitz,Kathryn L. Lunetta,Kathryn L. Lunetta,Patrick T. Ellinor,Patrick T. Ellinor +260 more
TL;DR: This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation that are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.
Journal ArticleDOI
The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi.
Jens Hellwage,Taru Meri,Tero Heikkilä,Antti Alitalo,Jaana Panelius,Jaana Panelius,Pekka Lahdenne,Ilkka Seppälä,Ilkka Seppälä,Seppo Meri,Seppo Meri +10 more
TL;DR: Specific binding of factor H to B. burgdorferi sensu stricto OspE may help the pathogen to evade complement attack and phagocytosis.
Journal ArticleDOI
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Urmo Võsa,Annique Claringbould,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Roman Kreuzhuber,Roman Kreuzhuber,Seyhan Yazar,Harm Brugge,Roy Oelen,Dylan H. de Vries,Monique G. P. van der Wijst,Silva Kasela,Natalia Pervjakova,Isabel Alves,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Hanieh Yaghootkar,Hanieh Yaghootkar,Reyhan Sönmez Flitman,Reyhan Sönmez Flitman,Andrew A. Brown,Andrew A. Brown,Viktorija Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg,Johannes Kettunen,Bernett Lee,Futao Zhang,Ting Qi,Jose Alquicira Hernandez,Wibowo Arindrarto,Frank Beutner,Peter A C 't Hoen,Joyce B. J. van Meurs,Jenny van Dongen,Maarten van Iterson,Morris A. Swertz,Julia Dmitrieva,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Alex W. Hewitt,Mika Kähönen,Yungil Kim,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Urko M. Marigorta,Hailang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Olli T. Raitakari,Olaf Rötzschke,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Joachim Thiery,Anke Tönjes,Jan H. Veldink,Uwe Völker,Robert Warmerdam,Cisca Wijmenga,Morris Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Zoltán Kutalik,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Sven Bergmann,Sven Bergmann,Timothy M. Frayling,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,Dorret I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Kate Downes,Kate Downes,Oliver Stegle,Oliver Stegle,Alexis Battle,Peter M. Visscher,Jian Yang,Jian Yang,Markus Scholz,Joseph E. Powell,Joseph E. Powell,Greg Gibson,Tõnu Esko,Lude Franke +126 more
TL;DR: In this article, the authors performed cis-and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium.