S
Serge L. Beaucage
Researcher at Food and Drug Administration
Publications - 99
Citations - 10663
Serge L. Beaucage is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Phosphoramidite & Deoxyribonucleoside. The author has an hindex of 34, co-authored 92 publications receiving 10426 citations. Previous affiliations of Serge L. Beaucage include Center for Drug Evaluation and Research & Westport Innovations.
Papers
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Journal ArticleDOI
Synthesis of (2-deoxy-alpha - and -beta -d-erythro-pentofuranosyl)(thymin-1-yl)alkanes and their incorporation into oligodeoxyribonucleotides. effect of nucleobase-sugar linker flexibility on the formation of dna-dna and dna- rna hybrids
Jila H. Boal,Andrzej Wilk,Carlo L. Scremin,Glenn N. Gray,Lawrence R. Phillips,Serge L. Beaucage +5 more
TL;DR: The insertion of 2a into 31 according to a (3‘ → 3‘)-orientation generated, for the first time, an altDNA oligonucleotide displaying a greater affinity for its RNA sequence than for the corresponding RNA sequence.
Journal ArticleDOI
The Synthesis of Modified Oligonucleotides by the Phosphoramidite Approach and Their Applications
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The Functionalization of Oligonucleotides via Phosphoramidite Derivatives
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Conceptual "Heat-Driven" approach to the synthesis of DNA oligonucleotides on microarrays.
Andrzej Grajkowski,Jacek Cieślak,Marcin K. Chmielewski,Vicente Marchán,Lawrence R. Phillips,Andrzej Wilk,Serge L. Beaucage +6 more
TL;DR: Progress has been made toward the use of deoxyribonucleoside cyclic N‐acylphosphoramidites in solid‐phase oligonucleotide syntheses without nucleobase protection, and blocking the 5′‐hydroxyl of these monomers with the thermolabile 1‐phenyl‐2‐[N‐methyl‐N‐(2‐pyridyl)]aminoethyloxycarbonyl group may provide a convenient thermo‐
Patent
Phosphoramidite compounds and their use in producing oligonucleotides
TL;DR: Hosphoramidite compounds are derivatives of saturated secondary amines and are used in the production of oligonucleotides as discussed by the authors, which is a type of nucleotides.