S
Serge L. Beaucage
Researcher at Food and Drug Administration
Publications - 99
Citations - 10663
Serge L. Beaucage is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Phosphoramidite & Deoxyribonucleoside. The author has an hindex of 34, co-authored 92 publications receiving 10426 citations. Previous affiliations of Serge L. Beaucage include Center for Drug Evaluation and Research & Westport Innovations.
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Journal ArticleDOI
Conceptual basis of the selective activation of bis(dialkylamino)methoxyphosphines by weak acids and its application toward the preparation of deoxynucleoside phosphoramidites in situ
Patent
Method for the sulfurization of phosphorous groups in compounds
TL;DR: In this paper, a method for the sulfurization of a phosphorus containing compound, which comprises: solubilizing the phosphorous containing compound and then contacting the sulfate containing compound with a sulfur containing compound of the solution formula, is described.
Journal ArticleDOI
Stepwise Regeneration and Recovery of Deoxyribonucleoside Phosphoramidite Monomers During Solid-Phase Oligonucleotide Synthesis
TL;DR: Deoxyribonucleoside phosphoramidites 1a-d have been regenerated, in a stepwise manner, during solid-phase oligonucleotide synthesis and have been efficiently reutilized in the solid- phase synthesis of polydeoxy ribonucleotides.
Journal ArticleDOI
N-Trifluoroacetylamino Alcohols as Phosphodiester Protecting Groups in the Synthesis of Oligodeoxyribonucleotides
Journal ArticleDOI
Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.
Andrzej Grajkowski,Jacek Cieślak,Jon S. Kauffman,Robert J. Duff,Scott E. Norris,Darón I. Freedberg,Serge L. Beaucage +6 more
TL;DR: The functionalization of long chain alkylamine controlled-pore glass (CPG) with a 3-hydroxypropyl-(2-cyanoethyl)thiophosphoryl linker and its conversion to the support 7 has led to the synthesis of DNA oligonucleotides and their 3'- or (3',5')-conjugates.