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Serge L. Beaucage
Researcher at Food and Drug Administration
Publications - 99
Citations - 10663
Serge L. Beaucage is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Phosphoramidite & Deoxyribonucleoside. The author has an hindex of 34, co-authored 92 publications receiving 10426 citations. Previous affiliations of Serge L. Beaucage include Center for Drug Evaluation and Research & Westport Innovations.
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Journal ArticleDOI
On the Quality Control of Antisense Oligonucleotides
Fritz Eckstein,Arthur M. Krieg,C. A. Stein,Sudhir Agrawal,Serge L. Beaucage,P. Dan Cook,Staney Crooke,Michael J. Gait,A. M. Gewirtz,Paul Hélène,Ramaswany Miller,Angelo Nicolin,Peter E. Nielsen,Eiko Ohtsuka,Hartmut Seliger,Wojciech J. Stec,David Tidd,Richard K. Wagner,Jerry Zon +18 more
Journal ArticleDOI
Fluoride ion-promoted transesterification in phosphate triesters
TL;DR: Phenyl groups are readily replaced in phosphate triesters by alcohols in general in the presence of casesium fluoride as discussed by the authors, in which casesium fluoride is used as an additive.
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3H‐1,2‐Benzodithiole‐3‐one 1,1‐Dioxide as an Improved Sulfurizing Reagent in the Solid‐Phase Synthesis of Oligodeoxyribonucleoside Phosphorothioates.
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UNIT 2.7 Deoxyribonucleoside Phosphoramidites
Andrzej Wilk,Andrzej Grajkowski,Marcin K. Chmielewski,Serge L. Beaucage,Lawrence R. Phillips +4 more
TL;DR: Two syntheses of phosphoramidites starting from either a phosphordichloridite precursor or a bis‐(N,N‐diisopropylamino)chlorophosphine intermediate are described for the phosphinylation of suitably protected deoxyribonucleosides.