S
Serge L. Beaucage
Researcher at Food and Drug Administration
Publications - 99
Citations - 10663
Serge L. Beaucage is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Phosphoramidite & Deoxyribonucleoside. The author has an hindex of 34, co-authored 92 publications receiving 10426 citations. Previous affiliations of Serge L. Beaucage include Center for Drug Evaluation and Research & Westport Innovations.
Papers
More filters
Journal ArticleDOI
[(2-Deoxy-α- and β-D-erythro-pentofuranosyl)thymin-1-YL] methane derivatives as potential conformational probes for altDNA oligonucleotides
TL;DR: In this paper, the previously unknown deoxyribonucleoside analogues 2a,b have been efficiently synthesized from commercial 1-O-methyl-2-deoxy-3,5-di O-p-toluoyl-D-erythro-pentofuranose.
Journal ArticleDOI
Large-scale preparation of the sulfur-transfer reagent 3h-1,2-benzodithiol-3-one 1,1-dioxide
TL;DR: In this article, a large scale preparation of the SULFUR-TRANSFER REAGENT 3H-1,2-BENZODITHIOL-3-ONE 1,1-DIOXIDE is described.
Journal ArticleDOI
31P NMR study of the desulfurization of oligonucleoside phosphorothioates effected by "aged" trichloroacetic acid solutions.
Jacek Cieślak,Cristina Ausín,Marcin K. Chmielewski,Jon S. Kauffman,John Snyder,¶ and Alfred Del-Grosso,Serge L. Beaucage +6 more
TL;DR: When employing phosphoramidites 1a-d in the solid-phase synthesis of oligonucleoside phosphorothioates, the thermolytic 2-[N-methyl-N-(2-pyridyl)]aminoethyl thiophosphate protecting group is lost to a large extent during the course of the synthesis.
Journal ArticleDOI
Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides.
Montserrat Puig,Suryatheja Ananthula,Ramesh Venna,Swamy K. Polumuri,Elliot Mattson,Lacey M Walker,Marco Cardone,Mayumi Takahashi,Shan Su,Lisa F. Boyd,Kannan Natarajan,Galina Abdoulaeva,Wells W. Wu,Gregory Roderiquez,William H. Hildebrand,Serge L. Beaucage,Zhihua Li,David H. Margulies,Michael A. Norcross +18 more
TL;DR: This paper used mass spectrometry to characterize the proteome and immunopeptidome of B-lymphoblastoid cells solely expressing HLA-B*57:01 as MHC-I molecules.