S
Serge L. Beaucage
Researcher at Food and Drug Administration
Publications - 99
Citations - 10663
Serge L. Beaucage is an academic researcher from Food and Drug Administration. The author has contributed to research in topics: Phosphoramidite & Deoxyribonucleoside. The author has an hindex of 34, co-authored 92 publications receiving 10426 citations. Previous affiliations of Serge L. Beaucage include Center for Drug Evaluation and Research & Westport Innovations.
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The synthesis of modified oligonucleotides by the phosphoramidite approach and their applications
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The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer reagent
TL;DR: Several polysulfides were tested as potential sulfur-transfer reagents during the automated synthesis of oligodeoxyribonucleoside phosphorothioates via the deoxyriboenucleosides phosphoramidite approach as discussed by the authors, and thiosulfonate 3H-1,2-benzodithiol-3-one 1,1-dioxide (12) was particularly efficient as a sulfurizing reagent
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The synthesis of oligoribonucleotides. II. The use of silyl protecting groups in nucleoside and nucleotide chemistry. VII
TL;DR: The synthesis of oligonucleotides derived from uridine and adenosine using the tert-butyldimethylsilyl protecting group and the trichloroethylphosphorodichloridite condensation procedure was described in this paper.
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Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis
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Strategies in the preparation of DNA oligonucleotide arrays for diagnostic applications.
TL;DR: Sensitive detection methods such as the use of light-scattering techniques, molecular beacons, surface plasmon resonance, attenuated total internal reflection-FTIR, and the evanescent field excitation of fluorescence from surface-bound fluorophores have been developed to study the kinetics and specificity of hybridization events.