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Sergei Doulatov
Researcher at University of Washington
Publications - 50
Citations - 6704
Sergei Doulatov is an academic researcher from University of Washington. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 25, co-authored 42 publications receiving 5931 citations. Previous affiliations of Sergei Doulatov include University Health Network & Howard Hughes Medical Institute.
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Journal ArticleDOI
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang,Li Ding,Linda Holmfeldt,Gang Wu,Susan L. Heatley,Susan L. Heatley,Debbie Payne-Turner,John Easton,Xiang Chen,Jianmin Wang,Michael Rusch,Charles Lu,Shann Ching Chen,Lei Wei,J. Racquel Collins-Underwood,Jing Ma,Kathryn G. Roberts,Stanley Pounds,Anatoly Ulyanov,Jared Becksfort,Pankaj Gupta,Robert Huether,Richard W. Kriwacki,Matthew Parker,Daniel J. McGoldrick,David Zhao,Daniel Alford,Stephen Espy,Kiran Chand Bobba,Guangchun Song,Deqing Pei,Cheng Cheng,Stefan Roberts,Michael I. Barbato,Michael I. Barbato,Dario Campana,Dario Campana,Elaine Coustan-Smith,Elaine Coustan-Smith,Sheila A. Shurtleff,Susana C. Raimondi,Maria Kleppe,Maria Kleppe,Jan Cools,Kristin A. Shimano,Michelle L. Hermiston,Sergei Doulatov,Kolja Eppert,Elisa Laurenti,Faiyaz Notta,John E. Dick,Giuseppe Basso,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,Brent L. Wood,Stuart S. Winter,Kimberley P. Dunsmore,Robert S. Fulton,Lucinda Fulton,Xin Hong,Chris Harris,David J. Dooling,Kerri Ochoa,Kimberly J. Johnson,John C. Obenauer,William E. Evans,Ching-Hon Pui,Clayton W. Naeve,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Charles G. Mullighan +73 more
TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Journal ArticleDOI
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment.
Faiyaz Notta,Sergei Doulatov,Sergei Doulatov,Elisa Laurenti,Elisa Laurenti,Armando G. Poeppl,Igor Jurisica,Igor Jurisica,John E. Dick,John E. Dick +9 more
TL;DR: Proteins are identified that underlie the early commitment steps of human hematopoietic stem cell differentiation and will enable the investigation of the molecular determinants of HSCs, with a goal of developing stem cell–based therapeutics.
Journal ArticleDOI
Hematopoiesis: A Human Perspective
Sergei Doulatov,Faiyaz Notta,Faiyaz Notta,Elisa Laurenti,Elisa Laurenti,John E. Dick,John E. Dick +6 more
TL;DR: This work highlights 2 decades of studies focusing on isolation and molecular regulation of human HSCs, therapeutic applications, and early lineage commitment steps, and compares mouse and humanized models to identify both conserved and species-specific mechanisms that will aid future preclinical research.
Journal ArticleDOI
Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development
Sergei Doulatov,Faiyaz Notta,Faiyaz Notta,Kolja Eppert,Kolja Eppert,Linh T. Nguyen,Pamela S. Ohashi,John E. Dick,John E. Dick +8 more
TL;DR: A comprehensive analysis of the human hematopoietic hierarchy is provided by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow to show that human hepatopoiesis does not follow a rigid model of myeloid-lymphoid segregation.
Journal ArticleDOI
Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells
Faiyaz Notta,Faiyaz Notta,Charles G. Mullighan,Jean C.Y. Wang,Jean C.Y. Wang,Armando G. Poeppl,Sergei Doulatov,Sergei Doulatov,Letha A. Phillips,Jing Ma,Mark D. Minden,James R. Downing,John E. Dick,John E. Dick +13 more
TL;DR: Using xenografting and DNA copy number alteration (CNA) profiling of human BCR–ABL1 lymphoblastic leukaemia, it is demonstrated that genetic diversity occurs in functionally definedLeukaemia-initiating cells and that many diagnostic patient samples contain multiple genetically distinct leukaemogenesis-in initiating cell subclones.