K
Kristin A. Shimano
Researcher at University of California, San Francisco
Publications - 42
Citations - 2188
Kristin A. Shimano is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Internal medicine & Hematopoietic stem cell transplantation. The author has an hindex of 13, co-authored 33 publications receiving 1751 citations. Previous affiliations of Kristin A. Shimano include Boston Children's Hospital.
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Journal ArticleDOI
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Jinghui Zhang,Li Ding,Linda Holmfeldt,Gang Wu,Susan L. Heatley,Susan L. Heatley,Debbie Payne-Turner,John Easton,Xiang Chen,Jianmin Wang,Michael Rusch,Charles Lu,Shann Ching Chen,Lei Wei,J. Racquel Collins-Underwood,Jing Ma,Kathryn G. Roberts,Stanley Pounds,Anatoly Ulyanov,Jared Becksfort,Pankaj Gupta,Robert Huether,Richard W. Kriwacki,Matthew Parker,Daniel J. McGoldrick,David Zhao,Daniel Alford,Stephen Espy,Kiran Chand Bobba,Guangchun Song,Deqing Pei,Cheng Cheng,Stefan Roberts,Michael I. Barbato,Michael I. Barbato,Dario Campana,Dario Campana,Elaine Coustan-Smith,Elaine Coustan-Smith,Sheila A. Shurtleff,Susana C. Raimondi,Maria Kleppe,Maria Kleppe,Jan Cools,Kristin A. Shimano,Michelle L. Hermiston,Sergei Doulatov,Kolja Eppert,Elisa Laurenti,Faiyaz Notta,John E. Dick,Giuseppe Basso,Stephen P. Hunger,Mignon L. Loh,Meenakshi Devidas,Brent L. Wood,Stuart S. Winter,Kimberley P. Dunsmore,Robert S. Fulton,Lucinda Fulton,Xin Hong,Chris Harris,David J. Dooling,Kerri Ochoa,Kimberly J. Johnson,John C. Obenauer,William E. Evans,Ching-Hon Pui,Clayton W. Naeve,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Charles G. Mullighan +73 more
TL;DR: The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal andMyeloid leukaemia haematopoietic stem cells, suggesting that addition of myeloids-directed therapies might improve the poor outcome of E TP ALL.
Journal ArticleDOI
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
Cristina Delgado-Martin,Lauren K. Meyer,Benjamin J. Huang,Kristin A. Shimano,Matt S. Zinter,J V Nguyen,Geoffrey A. Smith,Jack Taunton,Stuart S. Winter,J R Roderick,Michelle A. Kelliher,Terzah M. Horton,Brent L. Wood,David T. Teachey,Michelle L. Hermiston +14 more
TL;DR: Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.
Journal ArticleDOI
Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children
Matt S. Zinter,Christopher C. Dvorak,Madeline Y. Mayday,Kensho Iwanaga,Ngoc P. Ly,Meghan E. McGarry,Gwynne D. Church,Lauren E Faricy,Courtney M. Rowan,Janet R. Hume,Marie E. Steiner,Emily D. Crawford,Charles Langelier,Katrina Kalantar,Eric D. Chow,Steve Miller,Kristin A. Shimano,Alexis Melton,Gregory A. Yanik,Anil Sapru,Anil Sapru,Joseph L. DeRisi +21 more
TL;DR: Zinter et al. as mentioned in this paper developed a highly sensitive metagenomic next-generation sequencing (mNGS) assay capable of evaluating the pulmonary microbiome and identifying diverse pathogens in the lungs of immunocompromised children.
Journal ArticleDOI
Daratumumab in life-threatening autoimmune hemolytic anemia following hematopoietic stem cell transplantation.
Catharina Schuetz,Manfred Hoenig,Despina Moshous,Despina Moshous,Christof Weinstock,Martin Castelle,Matthieu Bendavid,Kristin A. Shimano,Vanessa P. Tolbert,Ansgar Schulz,Christopher C. Dvorak +10 more
TL;DR: In potentially life-threatening AIHA in the context of HSCT, daratumumab may be an effective rescue therapy and described an innovative therapy for AIHA refractory to proteasome inhibition.
Journal ArticleDOI
Thrombopoietin Receptor Agonist Use in Children: Data from the Pediatric ITP Consortium of North America ICON2 Study
Cindy E. Neunert,Jenny M. Despotovic,Kristina M. Haley,Michele P. Lambert,Kerri Nottage,Kristin A. Shimano,Carolyn M. Bennett,Robert J. Klaassen,Kimo C. Stine,Alexis A. Thompson,Yves D. Pastore,Travis Brown,Peter W. Forbes,Rachael F. Grace +13 more
TL;DR: Thrombopoietin receptor agonists (TPO‐RA) provide a nonimmunosuppressive option for children who require an increased platelet count.