Sergei S. Makarov

TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.

TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.

TL;DR: The major COMT haplotypes varied with respect to messenger RNA local stem-loop structures, such that the most stable structure was associated with the lowest protein levels and enzymatic activity.

TL;DR: It is demonstrated that in vitro, NF-kappaB controlled expression of numerous inflammatory molecules in synoviocytes and protected cells against tumor necrosis factor alpha (TNFalpha) and Fas ligand (FasL) cytotoxicity, and indicated that the activation of NF- kappaB protected the cells in the synovium against apoptosis and provided the potential link between inflammation and hyperplasia.

TL;DR: The role of NF-κB in chronic inflammation was discussed in this paper, where the authors discussed the feasibility of therapeutic approaches based on specific suppression of the nuclear factor κB pathway.