S
Sergei S. Makarov
Researcher at Research Triangle Park
Publications - 36
Citations - 6963
Sergei S. Makarov is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Arthritis & Population. The author has an hindex of 21, co-authored 32 publications receiving 6527 citations. Previous affiliations of Sergei S. Makarov include Pfizer & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
TL;DR: A role for NF-κB in growth factor signalling is established and an anti-apoptotic Ras/PI(3)K/Akt/IKK/NF-κBs pathway is defined, thus linking anti-APoptotic signalling with transcription machinery.
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Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
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Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
Andrea G. Nackley,Svetlana A. Shabalina,Inna E. Tchivileva,K. Satterfield,O. Korchynskyi,Sergei S. Makarov,William Maixner,Luda Diatchenko +7 more
TL;DR: The major COMT haplotypes varied with respect to messenger RNA local stem-loop structures, such that the most stable structure was associated with the lowest protein levels and enzymatic activity.
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NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
Alexei Miagkov,Dmitry V. Kovalenko,Chadwick E. Brown,John R. Didsbury,John P. Cogswell,Stephen A. Stimpson,Albert S. Baldwin,Sergei S. Makarov +7 more
TL;DR: It is demonstrated that in vitro, NF-kappaB controlled expression of numerous inflammatory molecules in synoviocytes and protected cells against tumor necrosis factor alpha (TNFalpha) and Fas ligand (FasL) cytotoxicity, and indicated that the activation of NF- kappaB protected the cells in the synovium against apoptosis and provided the potential link between inflammation and hyperplasia.
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NF-κB as a therapeutic target in chronic inflammation: recent advances
TL;DR: The role of NF-κB in chronic inflammation was discussed in this paper, where the authors discussed the feasibility of therapeutic approaches based on specific suppression of the nuclear factor κB pathway.