V
Vanessa Carregaro
Researcher at University of São Paulo
Publications - 43
Citations - 1687
Vanessa Carregaro is an academic researcher from University of São Paulo. The author has contributed to research in topics: Immune system & Leishmania infantum. The author has an hindex of 21, co-authored 39 publications receiving 1445 citations. Previous affiliations of Vanessa Carregaro include National Institutes of Health.
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Journal ArticleDOI
Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania.
Djalma S. Lima-Junior,Diego L. Costa,Vanessa Carregaro,Larissa D. Cunha,Alexandre L. N. Silva,Tiago W. P. Mineo,Tiago W. P. Mineo,Fredy R. S. Gutierrez,Fredy R. S. Gutierrez,Maria Bellio,Karina R. Bortoluci,Richard A. Flavell,Marcelo T. Bozza,João Santana da Silva,Dario S. Zamboni +14 more
TL;DR: It is shown that the Nlrp3 inflammasome is activated in response to Leishmania infection and is important for the restriction of parasite replication both in macrophages and in vivo as demonstrated through the infection of inflammaome-deficient mice with Leishmaniasis.
Journal ArticleDOI
CCR5 plays a critical role in the development of myocarditis and host protection in mice infected with Trypanosoma cruzi.
Fabiana S. Machado,Natalia S. Koyama,Vanessa Carregaro,Beatriz Rossetti Ferreira,Cristiane M. Milanezi,Mauro M. Teixeira,Marcos A. Rossi,João Santana da Silva +7 more
TL;DR: It is suggested that CCR5 and its ligands play a central role in the control of T cell influx in T. cruzi-infected mice and may help in the design of drugs that prevent myocarditis and protect against the development of severe disease.
Journal ArticleDOI
Deconstructing tick saliva: non-protein molecules with potent immunomodulatory properties.
Carlo José Freire de Oliveira,Anderson Sá-Nunes,Ivo M.B. Francischetti,Vanessa Carregaro,Elen Anatriello,João Santana da Silva,Isabel Kinney Ferreira de Miranda Santos,José M. C. Ribeiro,Beatriz Rossetti Ferreira +8 more
TL;DR: The presence of non-protein molecules adenosine and PGE2 in tick saliva indicates an important evolutionary mechanism used by ticks to subvert host immune cells and allow them to successfully complete their blood meal and life cycle.
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Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells.
Guilherme D. Brand,Guilherme D. Brand,José Roberto S. A. Leite,José Roberto S. A. Leite,Luciano P. Silva,Luciano P. Silva,Sérgio de Albuquerque,Maura V. Prates,Maura V. Prates,Ricardo Bentes Azevedo,Vanessa Carregaro,João Santana da Silva,Vanuza C.L. Sá,Reuber Albuquerque Brandão,Carlos Bloch +14 more
TL;DR: DS 01 is a 29-residue-long peptide with a molecular mass of 2793 Da showing antibacterial properties against Gram-positive and Gram-negative bacteria in the range of 3-25 microm, suggesting its therapeutic value especially as an anti-T.
Journal ArticleDOI
Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis
Raphael S. Peres,Foo Y. Liew,Foo Y. Liew,Jhimmy Talbot,Vanessa Carregaro,Renê Donizeti Ribeiro de Oliveira,Sérgio C. L. Almeida,Rafael F. O. França,Paula B. Donate,Larissa G. Pinto,Flávia Isaura de Santi Ferreira,Diego L. Costa,Daniel P. Demarque,Dayana Rubio Gouvea,Norberto Peporine Lopes,Regina Helena Costa Queiroz,João Santana da Silva,Florêncio Figueiredo,José C. Alves-Filho,Thiago M. Cunha,S H Ferreira,Paulo Louzada-Junior,Fernando Q. Cunha +22 more
TL;DR: Methotrexate unresponsiveness in RA is associated with low expression of CD39 on Tregs and the decreased suppressive activity of these cells through reduced ADO production, providing hitherto unrecognized mechanism of immune regulation in RA and on mode of action of MTX.