S
Serkan Kir
Researcher at Harvard University
Publications - 20
Citations - 2740
Serkan Kir is an academic researcher from Harvard University. The author has contributed to research in topics: Wasting & Cachexia. The author has an hindex of 13, co-authored 15 publications receiving 2230 citations. Previous affiliations of Serkan Kir include University of Texas Southwestern Medical Center & Bilkent University.
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Journal ArticleDOI
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Serkan Kir,Sara A. Beddow,Varman T. Samuel,Paul E. Miller,Stephen F. Previs,Kelly Suino-Powell,H. Eric Xu,Gerald I. Shulman,Steven A. Kliewer,David J. Mangelsdorf +9 more
TL;DR: FGF19 treatment restored the loss of glycogen in diabetic animals lacking insulin and activates a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.
Journal ArticleDOI
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
Serkan Kir,James P. White,Sandra Kleiner,Lawrence Kazak,Paul Cohen,Vickie E. Baracos,Bruce M. Spiegelman +6 more
TL;DR: It is demonstrated that tumour-derived parathyroid-hormone-related protein (PTHrP) has an important role in wasting, through driving the expression of genes involved in thermogenesis in adipose tissues, and mediates energy wasting in fat tissues and contributes to the broader aspects of cancer cachexia.
Journal ArticleDOI
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy
TL;DR: Experiments reveal at least two domains in ULK1 which likely function via unique sets of effectors to regulate autophagy, consistent with a role downstream of mTOR.
Journal ArticleDOI
Parathyroid hormone directs bone marrow mesenchymal cell fate.
Yi Fan,Yi Fan,Jun-ichi Hanai,Phuong T. Le,Ruiye Bi,Ruiye Bi,David E. Maridas,Victoria E. DeMambro,Carolina A. Figueroa,Serkan Kir,Xuedong Zhou,Michael Mannstadt,Roland Baron,Roderick T. Bronson,Mark C. Horowitz,Joy Y. Wu,John P. Bilezikian,David W. Dempster,Clifford J. Rosen,Beate Lanske +19 more
TL;DR: M marrow adipocytes exhibit osteogenic and adipogenic characteristics, are uniquely responsive to PTH, and secrete RANKL, which reveals an important mechanism for PTH's therapeutic action through its ability to direct mesenchymal cell fate.
Journal ArticleDOI
The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling
Tingting Li,Sam R. Holmstrom,Serkan Kir,Michihisa Umetani,Daniel R. Schmidt,Steven A. Kliewer,David J. Mangelsdorf +6 more
TL;DR: Ex vivo analyses showed that T GR5 activation increased cAMP concentrations and caused smooth muscle relaxation in a TGR5-dependent manner, revealing a novel, gallbladder-intrinsic mechanism for regulating gallbladders contractility.