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Shahd Ashouokhi
Researcher at Weizmann Institute of Science
Publications - 4
Citations - 139
Shahd Ashouokhi is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 2 publications receiving 32 citations.
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Journal ArticleDOI
Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs
Shadi Tarazi,Alejandro Aguilera-Castrejon,Carine Joubran,Nadir Ghanem,Shahd Ashouokhi,Francesco Roncato,Emilie Wildschutz,Montaser Haddad,Bernardo Oldak,Elidet Gómez-César,Nir Livnat,Sergey Viukov,Dmitry Lukshtanov,Segev Naveh Tassa,Max Rose,Suhair Hanna,Calanit Raanan,Ori Brenner,Merav Kedmi,Hadas Keren-Shaul,Tsvee Lapidot,Itay Maza,Noa Novershtern,Jacob H. Hanna +23 more
TL;DR: In this article , the authors adapt a recently established platform for prolonged ex utero growth of natural embryos to generate mouse post-gastrulation synthetic whole embryo models (sEmbryos), with both embryonic and extra-embryonic compartments, starting solely from naive ESCs.
Journal ArticleDOI
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Jonathan Bayerl,Muneef Ayyash,Tom Shani,Yair S. Manor,Ohad Gafni,Rada Massarwa,Yael Kalma,Alejandro Aguilera-Castrejon,Mirie Zerbib,Hadar Amir,Daoud Sheban,Shay Geula,Nofar Mor,Leehee Weinberger,Segev Naveh Tassa,Vladislav Krupalnik,Bernardo Oldak,Nir Livnat,Shadi Tarazi,Shadi Tawil,Emilie Wildschutz,Shahd Ashouokhi,Lior Lasman,Varda Rotter,Suhair Hanna,Dalit Ben-Yosef,Noa Novershtern,Sergey Viukov,Jacob H. Hanna +28 more
TL;DR: In this article, MeK/ERK inhibition is substituted with the inhibition of NOTCH/RBPj, which induces alternative naive-like hPSCs with a diminished risk for deleterious global DNA hypomethylation.
Journal ArticleDOI
Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis
Alejandro Aguilera-Castrejon,Bernardo Oldak,Tom Shani,Nadir Ghanem,Chen Itzkovich,Sharon Slomovich,Shadi Tarazi,Jonathan Bayerl,Valeriya Chugaeva,Muneef Ayyash,Shahd Ashouokhi,Daoud Sheban,Nir Livnat,Lior Lasman,Sergey Viukov,Mirie Zerbib,Yoseph Addadi,Yoach Rais,Saifeng Cheng,Yonatan Stelzer,Hadas Keren-Shaul,Raanan Shlomo,Rada Massarwa,Noa Novershtern,Itay Maza,Itay Maza,Jacob H. Hanna +26 more
TL;DR: In this article, the authors present highly effective platforms for the ex-utero culture of post-implantation mouse embryos, which enable the appropriate development of embryos from before gastrulation (embryonic day (E) 5.5) until the hindlimb formation stage (E11).
Posted ContentDOI
Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCs
Bernardo Oldak,Emilie Wildschutz,Alejandro Aguilera-Castrejon,Chengming Zhao,Shadi Tarazi,Shahd Ashouokhi,Francesco Roncato,Sergey Viukov,Max Rose,Nir Livnat,Tom Shani,Carine Joubran,Yoseph Addadi,Merav Kedmi,Hadas Keren-Shaul,Sophie Petropoulos,Fredrik Lanner,Noa Novershtern,Jacob H. Hanna +18 more
TL;DR: In this article , a Stem cell-derived Embryo Models (SEMs) were used to study early human post-implantation development, including epiblast, hypoblast, extra-embryonic mesoderm, and trophoblast surrounding the latter layers.