Yair S. Manor

TL;DR: It is shown that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition from the pluripotent to the differentiated state.

TL;DR: The novel naive pluripotent cells validated herein retain molecular characteristics and functional properties that are highly similar to mouse naive ES cells, and distinct from conventional primed human pluripotency.

TL;DR: It is demonstrated that specification of hPGC-like cells (hPGCLCs) from germline competent pluripotent stem cells are consistent with the embryonic hPGCs and a germline seminoma that share a CD38 cell-surface marker, which collectively defines likely progression of the early human germline.

TL;DR: It is shown that chromosomal duplications are first acquired as a crude solution to stress, yet only as transient solutions that are eliminated and replaced by more efficient solutions obtained at the individual gene level, which indicates that aneuploidy is a useful yet short-lived intermediate that facilitates further adaptation.

TL;DR: In this article, MeK/ERK inhibition is substituted with the inhibition of NOTCH/RBPj, which induces alternative naive-like hPSCs with a diminished risk for deleterious global DNA hypomethylation.