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Shaila K. Mani
Researcher at Baylor College of Medicine
Publications - 43
Citations - 2052
Shaila K. Mani is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Receptor & Signal transduction. The author has an hindex of 26, co-authored 43 publications receiving 1908 citations. Previous affiliations of Shaila K. Mani include University of Texas at Austin & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Dopaminergic and ligand-independent activation of steroid hormone receptors.
TL;DR: In vitro, dopamine faithfully mimicked the effect of progesterone by causing a translocation of chicken progestersone receptor (cPR) from cytoplasm to nucleus, and a serine residue in the cPR was identified that is not necessary for progester one-dependent activation of cPR, but is essential for dopamine activation of this receptor.
Book ChapterDOI
An Alternative Ligand-Independent Pathway for Activation of Steroid Receptors
Bert W. O'Malley,William T. Schrader,Shaila K. Mani,Carolyn L. Smith,Nancy L. Weigel,Orla M. Conneely,James H. Clark +6 more
TL;DR: The steroid receptor pathway can be activated alternatively from the membrane via pathway convergence, but the average cell responses are likely to be more complicated.
Journal ArticleDOI
Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice
Xuehong Cao,Xuehong Cao,Pingwen Xu,Mario G. Oyola,Yan Xia,Xiaofeng Yan,Kenji Saito,Fang Zou,Chunmei Wang,Yongjie Yang,Antentor Othrell Hinton,Chunling Yan,Hongfang Ding,Liangru Zhu,Liangru Zhu,Likai Yu,Bin Yang,Yuxin Feng,Yuxin Feng,Deborah J. Clegg,Sohaib A. Khan,Richard D. DiMarchi,Shaila K. Mani,Qingchun Tong,Yong Xu +24 more
TL;DR: It is shown that estrogen replacement substantially suppresses binge-like eating behavior in ovariectomized female mice and suggests ERα and/or SK current in DRN 5-HT neurons as potential targets for anti-binge therapies.
Journal ArticleDOI
Oxytocin and Estrogen Receptor β in the Brain: An Overview.
TL;DR: A role for OT is found in this estrogen receptor β-mediated anxiolytic effect and further research is needed to identify modulators of OT signaling and the pathways utilized to allow better therapeutic manipulations of this system in patient populations.
Journal ArticleDOI
Anxiolytic effects and neuroanatomical targets of estrogen receptor-β (ERβ) activation by a selective ERβ agonist in female mice.
Mario G. Oyola,Wendy Portillo,Andrea Reyna,Chad D. Foradori,Andrea E. Kudwa,Laura R. Hinds,Robert J. Handa,Shaila K. Mani +7 more
TL;DR: These studies provide compelling evidence for anxiolytic effects mediated by ERβ, and its neuroanatomical targets, that send or receive projections to/from the paraventricular nucleus, providing potential indirect mode of action for the control of hypothalamo-pituitary-adrenal axis function and behaviors.