S
Shan Lu
Researcher at University of California, San Diego
Publications - 38
Citations - 1856
Shan Lu is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Computer science & Engineering. The author has an hindex of 15, co-authored 23 publications receiving 1096 citations. Previous affiliations of Shan Lu include Ludwig Institute for Cancer Research & Beijing Normal University.
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Journal ArticleDOI
Structure of the voltage-gated calcium channel Ca v 1.1 at 3.6 Å resolution
TL;DR: The atomic model of the Cav1.1 complex establishes a foundation for mechanistic understanding of excitation–contraction coupling and provides a three-dimensional template for molecular interpretations of the functions and disease mechanisms of Cav and Nav channels.
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Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death.
Fátima Gasset-Rosa,Shan Lu,Haiyang Yu,Cong Chen,Ze ev Melamed,Lin Guo,James Shorter,Sandrine Da Cruz,Don W. Cleveland +8 more
TL;DR: It is shown that TDP-43 at its endogenous level undergoes liquid-liquid phase separation (LLPS) within nuclei in multiple cell types and identifies a neuronal cell death mechanism that can be initiated by transient-stress-induced cytosolic de-mixing of T DP-43.
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The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein.
Shan Lu,Shan Lu,Qiaozhen Ye,Digvijay Singh,Yong Cao,Jolene K. Diedrich,John R. Yates,Elizabeth Villa,Don W. Cleveland,Don W. Cleveland,Kevin D. Corbett +10 more
TL;DR: In this paper, the authors demonstrate that the N protein's central disordered domain drives phase separation with RNA, and that phosphorylation of an adjacent serine/arginine rich region modulates the physical properties of the resulting condensates.
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HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
Haiyang Yu,Shan Lu,Kelsey Gasior,Digvijay Singh,Sonia Vazquez-Sanchez,Olga Tapia,Divek Toprani,Melinda S. Beccari,John R. Yates,Sandrine Da Cruz,Sandrine Da Cruz,Jay M. Newby,Miguel Lafarga,Amy S. Gladfelter,Amy S. Gladfelter,Elizabeth Villa,Don W. Cleveland +16 more
TL;DR: It is reported that an RNA-binding protein called TDP-43, in which mutation and aggregation are linked to amyotrophic lateral sclerosis and frontotemporal dementia, phase separates into complex droplets, which they named anisosomes.
Journal ArticleDOI
Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose
Ping Zhou,Yang She,Na Dong,Peng Li,Huabin He,Alessio Borio,Qingcui Wu,Shan Lu,Xiaojun Ding,Yong Cao,Yue Xu,Wenqing Gao,Meng-Qiu Dong,Jingjin Ding,Da-Cheng Wang,Alla Zamyatina,Feng Shao,Feng Shao +17 more
TL;DR: This work combined a transposon screen in Yersinia pseudotuberculosis with biochemical analyses and identified ADP-β-d-manno-heptose (ADP-Hep), which mediates type III secretion system-dependent NF-κB activation and cytokine expression.