S
Shankar Srinivas
Researcher at University of Oxford
Publications - 76
Citations - 7110
Shankar Srinivas is an academic researcher from University of Oxford. The author has contributed to research in topics: Endoderm & Epiblast. The author has an hindex of 28, co-authored 64 publications receiving 5885 citations. Previous affiliations of Shankar Srinivas include Columbia University & University of Cambridge.
Papers
More filters
Journal ArticleDOI
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Shankar Srinivas,Tomoko Watanabe,Chyuan-Sheng Lin,Chris M William,Yasuto Tanabe,Thomas M. Jessell,Frank Costantini +6 more
TL;DR: In contrast to existing lacZ reporter lines, where lacZ expression cannot easily be detected in living tissue, the EYFP and ECFP reporter strains are useful for monitoring the expression of Cre and tracing the lineage of these cells and their descendants in cultured embryos or organs.
Journal ArticleDOI
A single-cell molecular map of mouse gastrulation and early organogenesis.
Blanca Pijuan-Sala,Jonathan A. Griffiths,Carolina Guibentif,Tom W. Hiscock,Wajid Jawaid,Fernando J Calero-Nieto,Carla Mulas,Ximena Ibarra-Soria,Richard C. V. Tyser,Debbie Lee Lian Ho,Wolf Reik,Wolf Reik,Wolf Reik,Shankar Srinivas,Benjamin D. Simons,Jennifer Nichols,John C. Marioni,John C. Marioni,John C. Marioni,Berthold Göttgens +19 more
TL;DR: A comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine.
Journal ArticleDOI
Image-based adaptive optics for two-photon microscopy
Delphine Débarre,Edward J. Botcherby,Tomoko Watanabe,Shankar Srinivas,Martin J. Booth,Tony Wilson +5 more
TL;DR: Using analysis of the image-formation process, an optimized correction scheme permitting image-quality improvement with minimal additional exposure of the sample is developed and it is shown that this correction process induces little photobleaching and significantly improves the quality of images of biological samples.
Journal ArticleDOI
Vitamin A controls epithelial/mesenchymal interactions through Ret expression.
Ekatherina Batourina,Suzanna Gim,Natalie A. Bello,Michael E. Shy,Margaret Clagett-Dame,Shankar Srinivas,Frank Costantini,Cathy Mendelsohn +7 more
TL;DR: It is demonstrated that forced expression of Ret in mice deficient for both Rara and Rarb2 genetically rescues renal development, restoring ureteric bud growth and stromal cell patterning.
Journal ArticleDOI
Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis
E de Graaff,Shankar Srinivas,Carol Kilkenny,Vivette D. D'Agati,Baljinder S. Mankoo,Frank Costantini,Vassilis Pachnis +6 more
TL;DR: It is shown that RET9 and RET51 have different signaling properties in vivo and define specific temporal and spatial requirements of c-Ret function during renal development and histogenesis of the enteric nervous system.