Tom W. Hiscock

TL;DR: A comprehensive delineation of mammalian cell differentiation trajectories in vivo represents a baseline for understanding the effects of gene mutations during development, as well as a roadmap for the optimization of in vitro differentiation protocols for regenerative medicine.

TL;DR: AO-LLSM takes high-resolution live-cell imaging of subcellular processes from the confines of the coverslip to the more physiologically relevant 3D environment within whole transparent organisms and creates new opportunities to study the phenotypic diversity of intracellular dynamics, extracellular communication, and collective cell behavior across different cell types, organisms, and developmental stages.

TL;DR: This work identifies an evolvable design logic that enables robust cell-level regulation of tissue-level development and predicts that cell shape is robust to changes of tissue surface area, cell volume, and cell number, which is confirmed in vivo.

TL;DR: Results reveal the cellular mechanism through which ROCs form the wound epidermis and ensure successful regeneration of Xenopus tails after amputation, and identify a previously unrecognized cell type, which is termed regeneration-organizing cell (ROC).

TL;DR: This work uses a general model of periodic patterning to show that different types of mechanism can generate qualitatively similar final patterns, and suggests ways in which molecular, cellular or mechanical models can be tested.