S
Shannan L. Rossi
Researcher at University of Texas Medical Branch
Publications - 90
Citations - 5248
Shannan L. Rossi is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Zika virus & Virus. The author has an hindex of 33, co-authored 84 publications receiving 4269 citations. Previous affiliations of Shannan L. Rossi include University of Pittsburgh & Tulane University.
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Journal ArticleDOI
Characterization of a Novel Murine Model to Study Zika Virus
Shannan L. Rossi,Robert B. Tesh,Sasha R. Azar,Antonio E. Muruato,Kathryn A. Hanley,Albert J. Auguste,Rose M. Langsjoen,Slobodan Paessler,Nikos Vasilakis,Scott C. Weaver +9 more
TL;DR: Characterization of an Asian lineage ZIKV strain in a murine model, and one of the few studies reporting a model of Zika disease and demonstrating age-dependent morbidity and mortality, could provide a platform for testing the efficacy of antivirals and vaccines.
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A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection
Nicholas J. Barrows,Nicholas J. Barrows,Rafael K. Campos,Rafael K. Campos,Steven T. Powell,K. Reddisiva Prasanth,Geraldine Schott-Lerner,Ruben Soto-Acosta,Gaddiel Galarza-Muñoz,Erica L. McGrath,Rheanna Urrabaz-Garza,Junling Gao,Ping Wu,Ramkumar Menon,George R. Saade,Ildefonso Fernández-Salas,Shannan L. Rossi,Nikos Vasilakis,Andrew Routh,Shelton S. Bradrick,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +21 more
TL;DR: A library of FDA-approved drugs was interrogated for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7) and established anti-flaviviral drugs and others that had no previously known antiviral activity were identified as inhibitors of ZikV infection.
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An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors
Chao Shan,Xuping Xie,Antonio E. Muruato,Shannan L. Rossi,Christopher M. Roundy,Sasha R. Azar,Yujiao Yang,Robert B. Tesh,Nigel Bourne,Alan D.T. Barrett,Nikos Vasilakis,Scott C. Weaver,Pei Yong Shi +12 more
TL;DR: An infectious cDNA clone of ZIKV that was generated using a clinical isolate of the Asian lineage is reported, which may help identify viral determinants of human virulence and mosquito transmission as well as inform vaccine and therapeutic strategies.
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A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
Chao Shan,Antonio E. Muruato,Bruno Tardelli Diniz Nunes,Bruno Tardelli Diniz Nunes,Huanle Luo,Xuping Xie,Daniele Barbosa de Almeida Medeiros,Daniele Barbosa de Almeida Medeiros,Maki Wakamiya,Robert B. Tesh,Alan D.T. Barrett,Tian Wang,Scott C. Weaver,Pedro Fernando da Costa Vasconcelos,Pedro Fernando da Costa Vasconcelos,Shannan L. Rossi,Pei Yong Shi +16 more
TL;DR: The safety and efficacy results suggest that further development of this promising, live-attenuated ZIKV vaccine candidate is warranted.
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Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease
Justin M. Richner,Brett W. Jagger,Chao Shan,Camila R. Fontes,Kimberly A. Dowd,Bin Cao,Sunny Himansu,Elizabeth A. Caine,Bruno Tardelli Diniz Nunes,Bruno Tardelli Diniz Nunes,Daniele Barbosa de Almeida Medeiros,Daniele Barbosa de Almeida Medeiros,Antonio E. Muruato,Bryant M. Foreman,Huanle Luo,Tian Wang,Alan D.T. Barrett,Scott C. Weaver,Pedro Fernando da Costa Vasconcelos,Pedro Fernando da Costa Vasconcelos,Shannan L. Rossi,Giuseppe Ciaramella,Indira U. Mysorekar,Theodore C. Pierson,Pei Yong Shi,Michael S. Diamond +25 more
TL;DR: Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise.