G
Geraldine Schott-Lerner
Researcher at University of Texas Medical Branch
Publications - 4
Citations - 771
Geraldine Schott-Lerner is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Gene & Alternative splicing. The author has an hindex of 4, co-authored 4 publications receiving 611 citations.
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Journal ArticleDOI
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection
Nicholas J. Barrows,Nicholas J. Barrows,Rafael K. Campos,Rafael K. Campos,Steven T. Powell,K. Reddisiva Prasanth,Geraldine Schott-Lerner,Ruben Soto-Acosta,Gaddiel Galarza-Muñoz,Erica L. McGrath,Rheanna Urrabaz-Garza,Junling Gao,Ping Wu,Ramkumar Menon,George R. Saade,Ildefonso Fernández-Salas,Shannan L. Rossi,Nikos Vasilakis,Andrew Routh,Shelton S. Bradrick,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +21 more
TL;DR: A library of FDA-approved drugs was interrogated for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7) and established anti-flaviviral drugs and others that had no previously known antiviral activity were identified as inhibitors of ZikV infection.
Journal ArticleDOI
Biochemistry and Molecular Biology of Flaviviruses
Nicholas J. Barrows,Nicholas J. Barrows,Rafael K. Campos,Rafael K. Campos,Kuo-Chieh Liao,K. Reddisiva Prasanth,Ruben Soto-Acosta,Shih Chia Yeh,Geraldine Schott-Lerner,Julien Pompon,Julien Pompon,October M. Sessions,Shelton S. Bradrick,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +14 more
TL;DR: This review examines the molecular biology of flaviviruses touching on the structure and function of viral components and how these interact with host factors, and highlights the role of a noncoding RNA produced by flavIViruses to impair antiviral host immune responses.
Journal ArticleDOI
Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network.
Matthew T. Aliota,Leda Bassit,Shelton S. Bradrick,Bryan Cox,Mariano A. Garcia-Blanco,Christina Gavegnano,Thomas C. Friedrich,Thaddeus G. Golos,Diane E. Griffin,Diane E. Griffin,Andrew D. Haddow,Andrew D. Haddow,Esper G. Kallas,Esper G. Kallas,Uriel Kitron,Marc Lecuit,Marc Lecuit,Marc Lecuit,Diogo M. Magnani,Caroline Marrs,Natalia Mercer,Edward McSweegan,Lisa F. P. Ng,Lisa F. P. Ng,David H. O’Connor,Jorge E. Osorio,Jorge E. Osorio,Guilherme S. Ribeiro,Michael J. Ricciardi,Shannan L. Rossi,George R. Saade,Raymond F. Schinazi,Raymond F. Schinazi,Geraldine Schott-Lerner,Chao Shan,Pei Yong Shi,David I. Watkins,David I. Watkins,Nikos Vasilakis,Scott C. Weaver,Scott C. Weaver +40 more
TL;DR: The spectrum of primary ZIKV-induced disease in adults and children, sites of persistent infection and sexual transmission, and the likely future of the pandemic are reviewed.
Journal ArticleDOI
Human Epistatic Interaction Controls IL7R Splicing and Increases Multiple Sclerosis Risk
Gaddiel Galarza-Muñoz,Gaddiel Galarza-Muñoz,Farren B.S. Briggs,Irina Evsyukova,Geraldine Schott-Lerner,Edward M. Kennedy,Tinashe Nyanhete,Liuyang Wang,Laura Bergamaschi,Steven G. Widen,Georgia D. Tomaras,Dennis C. Ko,Shelton S. Bradrick,Shelton S. Bradrick,Lisa F. Barcellos,Simon G. Gregory,Mariano A. Garcia-Blanco,Mariano A. Garcia-Blanco +17 more
TL;DR: The RNA helicase DDX39B is identified as a potent activator of this exon and consequently a repressor of sIL7R, and strong genetic association of DDx39B with MS risk is found, and mechanistic insight is provided into the regulation of IL7R exon 6 splicing and its impact on MS risk.