Andrew Routh

TL;DR: This work reports a general method for the production of homogeneously and site-specifically acetylated recombinant histones by genetically encoding acetyl-lysine and demonstrates that, in contrast to the prevailing dogma, acetylation of H3 K56 does not directly affect the compaction of chromatin and has modest effects on remodeling by SWI/SNF and RSC.

TL;DR: In this paper, a mutant SARS-CoV-2 that lacks the furin cleavage site (ΔPRRA) was generated, which had faster kinetics, improved fitness in Vero E6 cells and reduced spike protein processing.

TL;DR: A library of FDA-approved drugs was interrogated for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7) and established anti-flaviviral drugs and others that had no previously known antiviral activity were identified as inhibitors of ZikV infection.

TL;DR: It is established that the compaction behavior is both NRL- and linker histone-dependent, and this observations provide an explanation for the distribution of NRLs found in nature.

TL;DR: It is found that compaction is regulated in two steps: Introduction of H4 acetylated to 30% on K16 inhibits compaction to a greater degree than deletion of the H4 N-terminal tail, and further decompaction is achieved by removal of the linker histone.